Coptisine

Also known as: Coptisine (P), Coptisin, Coptisine Sulfate, 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium, 5,6-Dihydro-2,3:9,10-bis(methylenedioxy)dibenzo[a,g]quinolizinium, Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium, 6,7-dihydro-, 6,7-Dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium, coptisinium

Coptisine (CAS 3486-66-6) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C19H14NO4 and a molecular weight of 320.32 g/mol. Key property: a melting point of 212-217℃. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 3486-66-6
Jingsj CID: J-1962610-9
Molecular Formula: C₁₉H₁₄NO₄
Molecular Weight: 320.32 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	212-217℃
PSA	40.80000
LogP	-0.87

Activity & Biological Data

Target	IDO:6.3 μM (IC50) IDO:5.8 μM (Ki)
Additional Information	[1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.

Target

IDO:6.3 μM (IC50) IDO:5.8 μM (Ki)

Additional Information

[1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. [2]. He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. [3]. Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.

Frequently Asked Questions

What is the CAS number of Coptisine?

The CAS number of Coptisine is 3486-66-6.

What are the molecular formula and molecular weight of Coptisine?

Coptisine has molecular formula C19H14NO4 and molecular weight 320.32 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Coptisine (CAS 3486-66-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1962610-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.