Apigenin

Also known as: 4',5,7-Trihydroxyflavone, 5,7,4'-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone, Apigenine, Versulin, Versuline, C.I. Natural Yellow 1, Chamomile, Celery seed extract, Pelargidenon 1449, Pelargidenone, T66 BO EVJ CR DQ& GQ IQ

Apigenin (CAS 520-36-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H10O5 and a molecular weight of 270.237 g/mol. Key properties include a melting point of >300 °C(lit.), a boiling point of 555.5±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 217.1±23.6 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 520-36-5
Jingsj CID: J-17025-2
Molecular Formula: C₁₅H₁₀O₅
Molecular Weight: 270.237 g/mol
Category: Organic Compounds
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	>300 °C(lit.)
Boiling Point	555.5±50.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	217.1±23.6 °C
Exact Mass	270.052826
PSA	90.90000
LogP	2.10
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.732
Additional Property	DMSO: 27 mg/mL

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	Ki: 2 μM (CYP2C9)[1]
Additional Information	[1]. Si D, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37(3):629-34. [2]. Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11(29):4461-4. [3]. Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.

Target

Ki: 2 μM (CYP2C9)[1]

Additional Information

[1]. Si D, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37(3):629-34. [2]. Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11(29):4461-4. [3]. Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.

Customs & Trade Information

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Apigenin?

The CAS number of Apigenin is 520-36-5.

What are the molecular formula and molecular weight of Apigenin?

Apigenin has molecular formula C15H10O5 and molecular weight 270.237 g/mol.

Is Apigenin hazardous?

Apigenin has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Apigenin?

For Apigenin, Upstream Products: Naringenin, 4',5,7-Trimethoxyflavone, 2-chloro-1-(2,4,6-trihydroxyphenyl)ethanone; Downstream Products: Flavokawain A, Luteolin, Acacetin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "Apigenin (CAS 520-36-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-17025-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.