7-Ethyl-10-hydroxycamptothecin

Also known as: SN-38, (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 7-Ethyl-10-hydroxy-CPT, Irinotecan active metabolite, EHCPT

7-Ethyl-10-hydroxycamptothecin (CAS 86639-52-3) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C22H20N2O5 and a molecular weight of 392.405 g/mol. Key properties include a melting point of 217 °C, a boiling point of 810.3±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 443.8±34.3 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 86639-52-3
Jingsj CID: J-1323512-6
Molecular Formula: C₂₂H₂₀N₂O₅
Molecular Weight: 392.405 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	217 °C
Boiling Point	810.3±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	443.8±34.3 °C
Exact Mass	392.137207
PSA	101.65000
LogP	2.31
Vapor Pressure	0.0±3.0 mmHg at 25°C
Refractive Index	1.738

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	Topoisomerase I
Additional Information	[1]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8. [2]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [3]. Stewart CF, et al. Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice. Cancer Chemother Pharmacol. 1997;40(3):259-65.

Target

Topoisomerase I

Additional Information

[1]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8. [2]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [3]. Stewart CF, et al. Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice. Cancer Chemother Pharmacol. 1997;40(3):259-65.

Customs & Trade Information

HS Code	2942000000

Frequently Asked Questions

What is the CAS number of 7-Ethyl-10-hydroxycamptothecin?

The CAS number of 7-Ethyl-10-hydroxycamptothecin is 86639-52-3.

What are the molecular formula and molecular weight of 7-Ethyl-10-hydroxycamptothecin?

7-Ethyl-10-hydroxycamptothecin has molecular formula C22H20N2O5 and molecular weight 392.405 g/mol.

Is 7-Ethyl-10-hydroxycamptothecin hazardous?

7-Ethyl-10-hydroxycamptothecin has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of 7-Ethyl-10-hydroxycamptothecin?

For 7-Ethyl-10-hydroxycamptothecin, Upstream Products: 7-Ethylcamptothecin, (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, Irinotecan hydrochloride; Downstream Products: Irinotecan, Irinotecan hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "7-Ethyl-10-hydroxycamptothecin (CAS 86639-52-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1323512-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.