Masoprocol

Also known as: Nordihydroguaiaretic acid, NDGA, meso-Nordihydroguaiaretic acid, 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol), 4-[4-(3,4-Dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol, CHX-100, meso-4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol

Masoprocol (CAS 27686-84-6) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C18H22O4 and a molecular weight of 302.36500 g/mol. Key properties include a melting point of 185.5ºC, a boiling point of 526.5ºC at 760 mmHg, a density of 1.241 g/cm3 and a flash point of 247.8ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 27686-84-6
Jingsj CID: J-11530-0
Molecular Formula: C₁₈H₂₂O₄
Molecular Weight: 302.36500 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	185.5ºC
Boiling Point	526.5ºC at 760 mmHg
Density	1.241 g/cm3
Flash Point	247.8ºC
Exact Mass	302.15200
PSA	80.92000
LogP	3.56640
Vapor Pressure	1.06E-11mmHg at 25°C
Refractive Index	1.626

Activity & Biological Data

Additional Information	[1]. Luo J, et al. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol. 1998 Apr 3;346(1):77-9. [2]. Reed MJ, et al. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42(1):102-6. [3]. Scribner KA, et al. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metabolism. 2000 Sep;49(9):1106-10.

Additional Information

[1]. Luo J, et al. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol. 1998 Apr 3;346(1):77-9. [2]. Reed MJ, et al. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42(1):102-6. [3]. Scribner KA, et al. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metabolism. 2000 Sep;49(9):1106-10.

Frequently Asked Questions

What is the CAS number of Masoprocol?

The CAS number of Masoprocol is 27686-84-6.

What are the molecular formula and molecular weight of Masoprocol?

Masoprocol has molecular formula C18H22O4 and molecular weight 302.36500 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Masoprocol (CAS 27686-84-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11530-0 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.