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trans-4-Hydroxy-D-proline

Also known as: H-D-Hyp-OH, (2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid, 4-hydroxy-D-proline, trans-D-4-hydroxyproline, trans-D-Hydroxyproline, D-Hydroxyproline

trans-4-Hydroxy-D-proline (CAS 3398-22-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C5H9NO3 and a molecular weight of 131.130 g/mol. Key properties include a melting point of 260°C, a boiling point of 355.2±42.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 168.6±27.9 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
3398-22-9
Jingsj CID
J-1072580-1
Molecular Formula
C5H9NO3
Molecular Weight
131.130 g/mol
Category
Organic Acids
Last updated
8/21/2026

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Physicochemical Properties

Melting Point260°C
Boiling Point355.2±42.0 °C at 760 mmHg
Density1.4±0.1 g/cm3
Flash Point168.6±27.9 °C
Exact Mass131.058243
PSA69.56000
LogP-1.84
Vapor Pressure0.0±1.8 mmHg at 25°C
Refractive Index1.540

GHS Safety & Compliance

Irritant / Health HazardSignal word: Danger
  • H302 — Harmful if swallowed
  • H315 — Causes skin irritation
  • H319 — Causes serious eye irritation
  • H334 — May cause allergy or asthma symptoms if inhaled
  • H335 — May cause respiratory irritation

Customs & Trade Information

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of trans-4-Hydroxy-D-proline?

The CAS number of trans-4-Hydroxy-D-proline is 3398-22-9.

What are the molecular formula and molecular weight of trans-4-Hydroxy-D-proline?

trans-4-Hydroxy-D-proline has molecular formula C5H9NO3 and molecular weight 131.130 g/mol.

Is trans-4-Hydroxy-D-proline hazardous?

trans-4-Hydroxy-D-proline has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of trans-4-Hydroxy-D-proline?

For trans-4-Hydroxy-D-proline, Downstream Products: trans-4-Hydroxy-D-proline methyl ester hydrochloride, Pyrrole-2-carboxylic acid, (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "trans-4-Hydroxy-D-proline (CAS 3398-22-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1072580-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.