Noscapine Hydrochloride Hydrate
那可丁盐酸盐 水合物
Also known as: Noscapine hydrochloride, (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone hydrochloride, Narcotine hydrochloride, Opian hydrochloride, Capval, Coscopin hydrochloride, Nectadon hydrochloride, Vadebex hydrochloride, Terbenol hydrochloride, Methoxyhydrastine hydrochloride, (5R)-5-[(1S)-4,5-Dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium chloride
Noscapine Hydrochloride Hydrate (CAS 912-60-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C22H24ClNO7 and a molecular weight of 449.882 g/mol. It is also known as Noscapine hydrochloride, (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone hydrochloride and Narcotine hydrochloride. Key properties include a melting point of 221-223ºC, a boiling point of 565.3ºC at 760mmHg, a density of 1.332g/cm3 and a flash point of 295.7ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 912-60-7
- Jingsj CID
- J-28086-4
- Molecular Formula
- C22H24ClNO7
- Chinese Name
- 那可丁盐酸盐 水合物
- Molecular Weight
- 449.882 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 221-223ºC |
|---|---|
| Boiling Point | 565.3ºC at 760mmHg |
| Density | 1.332g/cm3 |
| Flash Point | 295.7ºC |
| Exact Mass | 449.124115 |
| PSA | 75.69000 |
| LogP | 3.62170 |
| Additional Property | Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand. |
GHS Safety & Compliance
- H302 — Harmful if swallowed
Activity & Biological Data
| Target | Sigma opioid receptors[4]Bradykinin[5]Apoptosis[1] |
|---|---|
| Additional Information | [1]. Jaren W Landen, et al. Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth. Clin Cancer Res. 2004 Aug 1;10(15):5187-201. [2]. Yang Y, et al. CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism. Theranostics. 2015 Mar 2;5(7):656-666. [3]. Vartika Tomar, et al. Noscapine and Its Analogs as Chemotherapeutic Agent: Current Updates. Curr Top Med Chem. 2017;17(2):174-188. [4]. Bianca Lokhorst, et al. Interaction of OTC Drug Noscapine and Acenocoumarol and Phenprocoumon. Br J Clin Pharmacol. 2019 May;85(5):1041-1043. [5]. S A Ebrahimi, et al. Interaction of Noscapine With the Bradykinin Mediation of the Cough Response. Acta Physiol Hung. 2003;90(2):147-55. |
Frequently Asked Questions
What is the CAS number of Noscapine Hydrochloride Hydrate?
The CAS number of Noscapine Hydrochloride Hydrate is 912-60-7.
What are the molecular formula and molecular weight of Noscapine Hydrochloride Hydrate?
Noscapine Hydrochloride Hydrate has molecular formula C22H24ClNO7 and molecular weight 449.882 g/mol.
Is Noscapine Hydrochloride Hydrate hazardous?
Noscapine Hydrochloride Hydrate has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.
What are the upstream and downstream products of Noscapine Hydrochloride Hydrate?
For Noscapine Hydrochloride Hydrate, Downstream Products: Meconine.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Noscapine Hydrochloride Hydrate (CAS 912-60-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28086-4 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.