Pirarubicin

吡柔比星

Also known as: 4'-O-Tetrahydropyranyladriamycin, 4'-O-Tetrahydropyranyl Doxorubicin, Pirabucin, Pinorubicin, Tepirubicin, Theprubicin, Therarubicin, THP-ADM, THP-Adriamycin, 1609 RB, (8S,10S)-10-((3-Amino-2,3,6-trideoxy-4-O-((2R)-tetrahydro-2H-pyran-2-yl)-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, (1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranoside, MFCD00869742

Pirarubicin (CAS 72496-41-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C32H37NO12 and a molecular weight of 627.636 g/mol. It is also known as 4'-O-Tetrahydropyranyladriamycin, 4'-O-Tetrahydropyranyl Doxorubicin and Pirabucin. Key properties include a melting point of 188-192ºC (dec.), a boiling point of 834.7±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 458.6±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 72496-41-4
Jingsj CID: J-42090-5
Molecular Formula: C₃₂H₃₇NO₁₂
Chinese Name: 吡柔比星
Molecular Weight: 627.636 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	188-192ºC (dec.)
Boiling Point	834.7±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	458.6±34.3 °C
Exact Mass	627.231567
PSA	204.30000
LogP	3.85
Vapor Pressure	0.0±3.2 mmHg at 25°C
Refractive Index	1.671

Activity & Biological Data

Target	Topoisomerase II
Additional Information	[1]. Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35. [2]. Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8. [3]. Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5. [4]. Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.

Target

Topoisomerase II

Additional Information

[1]. Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35. [2]. Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8. [3]. Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5. [4]. Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.

Frequently Asked Questions

What is the CAS number of Pirarubicin?

The CAS number of Pirarubicin is 72496-41-4.

What are the molecular formula and molecular weight of Pirarubicin?

Pirarubicin has molecular formula C32H37NO12 and molecular weight 627.636 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Pirarubicin (CAS 72496-41-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-42090-5 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.