Doxapram hydrochloride monohydrate

Also known as: Doxapram hydrochloride hydrate, Dopram hydrochloride hydrate, Doxapram HCl, AHR 619, Stimulexin, Respiram hydrochloride hydrate, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate

Doxapram hydrochloride monohydrate (CAS 7081-53-0) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C24H33ClN2O3 and a molecular weight of 432.983 g/mol. Key property: a melting point of 217-219°. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 7081-53-0
Jingsj CID: J-1959763-0
Molecular Formula: C₂₄H₃₃ClN₂O₃
Molecular Weight: 432.983 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	217-219°
Exact Mass	432.217957
PSA	42.01000
LogP	3.78680
Additional Property	Soluble in water, in alcohol and in methylene chloride.

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Additional Information	[1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785. [2]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8. [3]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22.

Additional Information

[1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785. [2]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8. [3]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22.

Frequently Asked Questions

What is the CAS number of Doxapram hydrochloride monohydrate?

The CAS number of Doxapram hydrochloride monohydrate is 7081-53-0.

What are the molecular formula and molecular weight of Doxapram hydrochloride monohydrate?

Doxapram hydrochloride monohydrate has molecular formula C24H33ClN2O3 and molecular weight 432.983 g/mol.

Is Doxapram hydrochloride monohydrate hazardous?

Doxapram hydrochloride monohydrate has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Doxapram hydrochloride monohydrate (CAS 7081-53-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959763-0 (accessed 2026-10-29).

Data for reference only; verify product details with suppliers before purchase.