SB-505124

Also known as: SB505124, SB 505124, 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine, 2-(5-benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine, 2-[4-(1,3-benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine, 2-[4-(1,3-benzodioxol-5-yl)-2-(2-methyl-2-propanyl)-1H-imidazol-5-yl]-6-methylpyridine, TGF-beta RI Inhibitor III, SB-505124 hydrochloride hydrate (non-salt)

SB-505124 (CAS 694433-59-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H21N3O2 and a molecular weight of 335.400 g/mol. It is also known as SB505124, SB 505124 and 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine. Key properties include a boiling point of 509.7±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 180.5±20.4 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 694433-59-5
Jingsj CID: J-1657-9
Molecular Formula: C₂₀H₂₁N₃O₂
Molecular Weight: 335.400 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	509.7±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	180.5±20.4 °C
Exact Mass	335.163391
PSA	60.03000
LogP	4.77
Appearance	yellow
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.600
Storage Conditions	2-8°C
Additional Property	DMSO: >10mg/mL

Activity & Biological Data

Target	IC50: 129 nM (ALK4), 47 nM (ALK5)
Additional Information	[1]. DaCosta Byfield S, et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2004 Mar;65(3):744-52. [2]. Sutariya V, et al. Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery. Pharm Dev Technol. 2013 Jul-Aug;18(4):957-62. [3]. Sapitro J, et al. Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. Mol Vis. 2010 Sep 16;16:1880-92.

Target

IC50: 129 nM (ALK4), 47 nM (ALK5)

Additional Information

[1]. DaCosta Byfield S, et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2004 Mar;65(3):744-52. [2]. Sutariya V, et al. Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery. Pharm Dev Technol. 2013 Jul-Aug;18(4):957-62. [3]. Sapitro J, et al. Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. Mol Vis. 2010 Sep 16;16:1880-92.

Frequently Asked Questions

What is the CAS number of SB-505124?

The CAS number of SB-505124 is 694433-59-5.

What are the molecular formula and molecular weight of SB-505124?

SB-505124 has molecular formula C20H21N3O2 and molecular weight 335.400 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "SB-505124 (CAS 694433-59-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1657-9 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.