Amonafide

Also known as: AS1413, Xanafide, Nafidimide, Quinamed, NSC 308847, FA 142, 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-

Amonafide (CAS 69408-81-7) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C16H17N3O2 and a molecular weight of 283.325 g/mol. Key properties include a melting point of 162-164ºC, a boiling point of 500.2±35.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 256.3±25.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 69408-81-7
Jingsj CID: J-1962149-9
Molecular Formula: C₁₆H₁₇N₃O₂
Molecular Weight: 283.325 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	162-164ºC
Boiling Point	500.2±35.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	256.3±25.9 °C
Exact Mass	283.132080
PSA	68.33000
LogP	0.06
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.681
Storage Conditions	-20°C Freezer

Activity & Biological Data

Target	Topoisomerase II
Additional Information	[1]. Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003. [2]. Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47(4):1040-4. [3]. Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6(2):79-85.

Target

Topoisomerase II

Additional Information

[1]. Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003. [2]. Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47(4):1040-4. [3]. Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6(2):79-85.

Frequently Asked Questions

What is the CAS number of Amonafide?

The CAS number of Amonafide is 69408-81-7.

What are the molecular formula and molecular weight of Amonafide?

Amonafide has molecular formula C16H17N3O2 and molecular weight 283.325 g/mol.

What are the upstream and downstream products of Amonafide?

For Amonafide, Upstream Products: Mitonafide, 3-Nitro-1,8-naphthalic anhydride, N,N-Dimethylethylenediamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Amonafide (CAS 69408-81-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1962149-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.