Mitonafide

Also known as: Mitonafide, Nsc300288, N-(2-(Dimethylamino)ethyl)-3-nitronaphthalimide, 2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione, 2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione, 3-Nitro-N-(2-dimethylaminoethyl)-1,8-naphthalimide, M-4212, Aids-070527, Aids070527, Mitonafida, Mitonafidum

Mitonafide (CAS 54824-17-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C16H15N3O4 and a molecular weight of 313.30800 g/mol. Key properties include a boiling point of 496.8ºC at 760 mmHg, a density of 1.384g/cm3 and a flash point of 254.3ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 54824-17-8
Jingsj CID: J-1973097-3
Molecular Formula: C₁₆H₁₅N₃O₄
Molecular Weight: 313.30800 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	496.8ºC at 760 mmHg
Density	1.384g/cm3
Flash Point	254.3ºC
Exact Mass	313.10600
PSA	88.13000
LogP	1.94570
Refractive Index	1.667
Storage Conditions	2-8°C

Activity & Biological Data

Target	DNA and RNA synthesis[1]
Additional Information	[1]. Llombart M, et al. Phase I study of mitonafide in solid tumors. Invest New Drugs. 1992 Aug;10(3):177-81. [2]. inha BK, et al. Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. Biochem Pharmacol. 1985 Nov 1;34(21):3845-52. [3]. Rosell R, et al. Phase I study of mitonafide in 120 hour continuous infusion in non-small cell lung cancer. Invest New Drugs. 1992 Aug;10(3):171-5. [4]. Samanta S, et al. Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent. J Exp Ther Oncol. 2005;5(1):15-22. [5]. Pain A, et al. Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide as a rationally-designed anticancer agent. J Exp Clin Cancer Res. 2003 Sep;22(3):411-8. [6]. Xin M, et al. Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127051.

Target

DNA and RNA synthesis[1]

Additional Information

[1]. Llombart M, et al. Phase I study of mitonafide in solid tumors. Invest New Drugs. 1992 Aug;10(3):177-81. [2]. inha BK, et al. Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. Biochem Pharmacol. 1985 Nov 1;34(21):3845-52. [3]. Rosell R, et al. Phase I study of mitonafide in 120 hour continuous infusion in non-small cell lung cancer. Invest New Drugs. 1992 Aug;10(3):171-5. [4]. Samanta S, et al. Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent. J Exp Ther Oncol. 2005;5(1):15-22. [5]. Pain A, et al. Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide as a rationally-designed anticancer agent. J Exp Clin Cancer Res. 2003 Sep;22(3):411-8. [6]. Xin M, et al. Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127051.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Mitonafide?

The CAS number of Mitonafide is 54824-17-8.

What are the molecular formula and molecular weight of Mitonafide?

Mitonafide has molecular formula C16H15N3O4 and molecular weight 313.30800 g/mol.

What are the upstream and downstream products of Mitonafide?

For Mitonafide, Upstream Products: 3-Nitro-1,8-naphthalic anhydride, N,N-Dimethylethylenediamine; Downstream Products: Amonafide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Mitonafide (CAS 54824-17-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1973097-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.