Astemizole
Also known as: Hismanal, 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine, 1-(4-Fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, 1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole, R 43512, R43512, Alermizol, Astemisan, Astemison, Astemizol, Astemizolum, Laridal, Paralergin, Retolen, Histaminos
Astemizole (CAS 68844-77-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C28H31FN4O and a molecular weight of 458.57 g/mol. Key properties include a melting point of 172.9ºC, a boiling point of 627.3ºC at 760 mmHg, a density of 1.2 g/cm3 and a flash point of 333.2ºC. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 68844-77-9
- Jingsj CID
- J-49196-9
- Molecular Formula
- C28H31FN4O
- Molecular Weight
- 458.57 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 172.9ºC |
|---|---|
| Boiling Point | 627.3ºC at 760 mmHg |
| Density | 1.2 g/cm3 |
| Flash Point | 333.2ºC |
| Exact Mass | 458.24800 |
| PSA | 42.32000 |
| LogP | 5.36220 |
| Refractive Index | 1.623 |
| Additional Property | DMSO: >20mg/mL |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Additional Information | [1]. Laduron PM, et al. In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole. Mol Pharmacol. 1982 Mar;21(2):294-300. [2]. Richards DM, et al. Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1984 Jul;28(1):38-61. |
|---|
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Astemizole?
The CAS number of Astemizole is 68844-77-9.
What are the molecular formula and molecular weight of Astemizole?
Astemizole has molecular formula C28H31FN4O and molecular weight 458.57 g/mol.
Is Astemizole hazardous?
Astemizole has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of Astemizole?
For Astemizole, Upstream Products: Ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]piperidine-1-carboxylate, ethyl 4-(1H-benzimidazol-2-ylamino)piperidine-1-carboxylate, 4-Fluorobenzyl chloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Astemizole (CAS 68844-77-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49196-9 (accessed 2026-11-07).
Data for reference only; verify product details with suppliers before purchase.