Mitoxantrone

Also known as: 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthraquinone, DHAQ, MITOXANTRONUM, NSC-279836, 1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione

Mitoxantrone (CAS 65271-80-9) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C22H28N4O6 and a molecular weight of 444.481 g/mol. Key properties include a melting point of 170-174ºC, a boiling point of 805.7±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 441.1±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 65271-80-9
Jingsj CID: J-1975903-6
Molecular Formula: C₂₂H₂₈N₄O₆
Molecular Weight: 444.481 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	170-174ºC
Boiling Point	805.7±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	441.1±34.3 °C
Exact Mass	444.200897
PSA	163.18000
LogP	0.45
Vapor Pressure	0.0±3.0 mmHg at 25°C
Refractive Index	1.709
Storage Conditions	-20°C Freezer

Activity & Biological Data

Target	PKC:8.5 μM (IC50) Topoisomerase II
Additional Information	[1]. Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7. [2]. Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6. [3]. Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8. [4]. Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.

Target

PKC:8.5 μM (IC50) Topoisomerase II

Additional Information

[1]. Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7. [2]. Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6. [3]. Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8. [4]. Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.

Frequently Asked Questions

What is the CAS number of Mitoxantrone?

The CAS number of Mitoxantrone is 65271-80-9.

What are the molecular formula and molecular weight of Mitoxantrone?

Mitoxantrone has molecular formula C22H28N4O6 and molecular weight 444.481 g/mol.

What are the upstream and downstream products of Mitoxantrone?

For Mitoxantrone, Upstream Products: 2-(2-Aminoethylamino)ethanol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Mitoxantrone (CAS 65271-80-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975903-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.