Phlorizin

根皮苷

Also known as: Phloridzin, Phloretin-2'-β-D-glucopyranoside, Phloretin-2'-O-glucoside, Floridzin, NSC 2833, Phlorhizin, Phlorrhizin, 1-(2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone

Phlorizin (CAS 60-81-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H24O10 and a molecular weight of 436.409 g/mol. It is also known as Phloridzin, Phloretin-2'-β-D-glucopyranoside and Phloretin-2'-O-glucoside. Key properties include a melting point of 113-114 °C(lit.), a boiling point of 770.0±60.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 270.7±26.4 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 60-81-1
Jingsj CID: J-11780-7
Molecular Formula: C₂₁H₂₄O₁₀
Chinese Name: 根皮苷
Molecular Weight: 436.409 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	113-114 °C(lit.)
Boiling Point	770.0±60.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	270.7±26.4 °C
Exact Mass	436.136932
PSA	177.14000
LogP	0.45
Vapor Pressure	0.0±2.8 mmHg at 25°C
Refractive Index	1.686

Activity & Biological Data

Target	Ki: 300 nM (hSGLT1), 39 nM (hSGLT2)[1] Na+/K+-ATPase[2]
Additional Information	[1]. Pajor AM, et al. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar;324(3):985-91. [2]. Nakagawa A, et al. Localization of the phlorizin site on Na, K-ATPase in red cell membranes. J Biochem. 1977 May;81(5):1511-5. [3]. Chang WT, et al. Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages. Food Chem. 2012 Sep 15;134(2):972-9. [4]. Katsuda Y, et al. Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin. Exp Anim. 2015;64(2):161-9.

Target

Ki: 300 nM (hSGLT1), 39 nM (hSGLT2)[1] Na+/K+-ATPase[2]

Additional Information

[1]. Pajor AM, et al. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar;324(3):985-91. [2]. Nakagawa A, et al. Localization of the phlorizin site on Na, K-ATPase in red cell membranes. J Biochem. 1977 May;81(5):1511-5. [3]. Chang WT, et al. Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages. Food Chem. 2012 Sep 15;134(2):972-9. [4]. Katsuda Y, et al. Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin. Exp Anim. 2015;64(2):161-9.

Frequently Asked Questions

What is the CAS number of Phlorizin?

The CAS number of Phlorizin is 60-81-1.

What are the molecular formula and molecular weight of Phlorizin?

Phlorizin has molecular formula C21H24O10 and molecular weight 436.409 g/mol.

What are the upstream and downstream products of Phlorizin?

For Phlorizin, Upstream Products: 4-Hydroxybenzaldehyde; Downstream Products: Phloretin.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Phlorizin (CAS 60-81-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11780-7 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.