Estrone-2,4,16,16-d4

Also known as: Estrone-d4, ESTRONE-2,4,16,16-D4, 3-Hydroxyestra-1,3,5(10)-trien-17-one-d4, 3-Hydroxy-17-keto-estra-1,3,5-triene-d4, Aquacrine-d4, Crinovaryl-d4, Wynestron-d4, Estra-1,3,5(10)-trien-17-one-2,4,16,16-d4, 3-hydroxy-, 1,3,5(10)-Estratrien-3-ol-17-one-d4

Estrone-2,4,16,16-d4 (CAS 53866-34-5) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C18H18D4O2 and a molecular weight of 274.391 g/mol. Key properties include a melting point of 258-260ºC(lit.), a boiling point of 445.2±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 189.7±21.3 °C. It is classified under GHS with signal word Danger and hazard statements H350 — May cause cancer and H360 — May damage fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 53866-34-5
Jingsj CID: J-29017-5
Molecular Formula: C₁₈H₁₈D₄O₂
Molecular Weight: 274.391 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	258-260ºC(lit.)
Boiling Point	445.2±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	189.7±21.3 °C
Exact Mass	274.187073
PSA	37.30000
LogP	3.69
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.587

GHS Safety & Compliance

Health HazardSignal word: Danger

H350 — May cause cancer
H360 — May damage fertility or the unborn child

Activity & Biological Data

Additional Information	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45(11):3341-3350. [3]. de Padua Mansur A, et al. Long-term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease. ScientificWorldJournal. 2012;2012:363595.

Additional Information

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Caupos E, et al. Photodegradation of estrone enhanced by dissolved organic matter under simulated sunlight. Water Res. 2011;45(11):3341-3350. [3]. de Padua Mansur A, et al. Long-term prospective study of the influence of estrone levels on events in postmenopausal women with or at high risk for coronary artery disease. ScientificWorldJournal. 2012;2012:363595.

Frequently Asked Questions

What is the CAS number of Estrone-2,4,16,16-d4?

The CAS number of Estrone-2,4,16,16-d4 is 53866-34-5.

What are the molecular formula and molecular weight of Estrone-2,4,16,16-d4?

Estrone-2,4,16,16-d4 has molecular formula C18H18D4O2 and molecular weight 274.391 g/mol.

Is Estrone-2,4,16,16-d4 hazardous?

Estrone-2,4,16,16-d4 has GHS signal word Danger and hazard statements H350 — May cause cancer; H360 — May damage fertility or the unborn child.

What are the upstream and downstream products of Estrone-2,4,16,16-d4?

For Estrone-2,4,16,16-d4, Upstream Products: Estrone, Estrone-16,16-d2; Downstream Products: 17β-Estradiol-2,4,16,16,17-d5.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Estrone-2,4,16,16-d4 (CAS 53866-34-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-29017-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.