17β-Estradiol-2,4,16,16,17-d5

Also known as: 17β-Estradiol-d5, D5-17-β-Estradiol, [2H5]-17-β-Estradiol, [2H5]-17-beta-Estradiol, 17β-Estradiol-D5 solution, 17beta-Estradiol-D5 solution, 17β-Estradiol-2,4,16,16,17-D5, 2,4,16,16,17-2H-estradiol-17β, 17β-Estradiol-2?4?16?16?17-[d5], 17beta-Estradiol-2,4,16,16,17-d5, (17β)-2,4,16,16,17-pentadeuterioestra-1,3,5(10)-triene-3,17-diol, (8R,9S,13S,14S,17S)-2,4,16,16,17-pentadeuterio-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3,17-diol

17β-Estradiol-2,4,16,16,17-d5 (CAS 221093-45-4) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C18H19D5O2 and a molecular weight of 277.41 g/mol. Key properties include a melting point of 178-179ºC(lit.), a boiling point of 445.9±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 209.6±23.3 °C. It is classified under GHS with signal word Danger and hazard statements H350 — May cause cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 221093-45-4
Jingsj CID: J-1958308-5
Molecular Formula: C₁₈H₁₉D₅O₂
Molecular Weight: 277.41 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	178-179ºC(lit.)
Boiling Point	445.9±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	209.6±23.3 °C
Exact Mass	277.209015
PSA	40.46000
LogP	4.13
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.599
Storage Conditions	?20°C

GHS Safety & Compliance

Health HazardSignal word: Danger

H350 — May cause cancer

Activity & Biological Data

Additional Information	[1]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12. [2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [3]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133. [4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [5]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [6]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [7]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

Additional Information

[1]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12. [2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [3]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133. [4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [5]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [6]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [7]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

Frequently Asked Questions

What is the CAS number of 17β-Estradiol-2,4,16,16,17-d5?

The CAS number of 17β-Estradiol-2,4,16,16,17-d5 is 221093-45-4.

What are the molecular formula and molecular weight of 17β-Estradiol-2,4,16,16,17-d5?

17β-Estradiol-2,4,16,16,17-d5 has molecular formula C18H19D5O2 and molecular weight 277.41 g/mol.

Is 17β-Estradiol-2,4,16,16,17-d5 hazardous?

17β-Estradiol-2,4,16,16,17-d5 has GHS signal word Danger and hazard statements H350 — May cause cancer.

What are the upstream and downstream products of 17β-Estradiol-2,4,16,16,17-d5?

For 17β-Estradiol-2,4,16,16,17-d5, Upstream Products: Estrone-2,4,16,16-d4.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "17β-Estradiol-2,4,16,16,17-d5 (CAS 221093-45-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958308-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.