Spiramide

螺拉米特

Also known as: AMI-193, Espiramida, Spiramidum, R 5808, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-

Spiramide (CAS 510-74-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H26FN3O2 and a molecular weight of 383.45900 g/mol. It is also known as AMI-193, Espiramida and Spiramidum. Key properties include a boiling point of 609.1ºC at 760 mmHg, a density of 1.26 g/cm3 and a flash point of 322.2ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 510-74-7
Jingsj CID: J-24975-7
Molecular Formula: C₂₂H₂₆FN₃O₂
Chinese Name: 螺拉米特
Molecular Weight: 383.45900 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	609.1ºC at 760 mmHg
Density	1.26 g/cm3
Flash Point	322.2ºC
Exact Mass	383.20100
PSA	44.81000
LogP	3.35480
Refractive Index	1.621

Activity & Biological Data

Target	5-HT2 Receptor:2 nM (Ki) D2 Receptor:3 nM (Ki) 5-HT1A Receptor:50 nM (Ki) D1 Receptor:2530 nM (Ki) 5-HT1C Receptor:4300 nM (Ki)
Additional Information	[1]. Ismaiel AM, et, al. Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J Med Chem. 1993 Aug 20;36(17):2519-25. [2]. Czoty PW, et, al. Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey. Pharmacol Biochem Behav. 2000 Oct;67(2):257-64. [3]. Kjellberg B, et, al. Partial restoration by a neuroleptic (spiramide) of items of grooming behaviour suppressed by amphetamine. Arch Int Pharmacodyn Ther. 1974 Jul;210(1):61-6.

Target

5-HT2 Receptor:2 nM (Ki) D2 Receptor:3 nM (Ki) 5-HT1A Receptor:50 nM (Ki) D1 Receptor:2530 nM (Ki) 5-HT1C Receptor:4300 nM (Ki)

Additional Information

[1]. Ismaiel AM, et, al. Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J Med Chem. 1993 Aug 20;36(17):2519-25. [2]. Czoty PW, et, al. Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey. Pharmacol Biochem Behav. 2000 Oct;67(2):257-64. [3]. Kjellberg B, et, al. Partial restoration by a neuroleptic (spiramide) of items of grooming behaviour suppressed by amphetamine. Arch Int Pharmacodyn Ther. 1974 Jul;210(1):61-6.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Spiramide?

The CAS number of Spiramide is 510-74-7.

What are the molecular formula and molecular weight of Spiramide?

Spiramide has molecular formula C22H26FN3O2 and molecular weight 383.45900 g/mol.

What are the upstream and downstream products of Spiramide?

For Spiramide, Upstream Products: 1-(3-Chloropropoxy)-4-fluorobenzene, 1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Spiramide (CAS 510-74-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-24975-7 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.