Proguanil

Also known as: 1-(p-chlorophenyl)-5-isopropyl-biguanid, 1-(p-chlorophenyl)-5-isopropylbiguanide, Chlorguanide-D6Cl, ChlorguanideCl, EINECS 207-915-6, N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE, PROGUANIL, bigumal, chlorguanide, chloroguanide, paludrine, proguanil

Proguanil (CAS 500-92-5) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C11H16ClN5 and a molecular weight of 253.73100 g/mol. Key properties include a melting point of 129°, a boiling point of 402.7ºC at 760mmHg, a density of 1.29g/cm3 and a flash point of 197.4ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 500-92-5
Jingsj CID: J-46089-7
Molecular Formula: C₁₁H₁₆ClN₅
Molecular Weight: 253.73100 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	129°
Boiling Point	402.7ºC at 760mmHg
Density	1.29g/cm3
Flash Point	197.4ºC
Exact Mass	253.10900
PSA	83.79000
LogP	3.26330
Refractive Index	1.6110 (estimate)
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12. [2]. Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9. [3]. Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351(3):674-84. [4]. Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36(5):587-99. [5]. Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197(3-4):527-33.

Additional Information

[1]. Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12. [2]. Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9. [3]. Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351(3):674-84. [4]. Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36(5):587-99. [5]. Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197(3-4):527-33.

Frequently Asked Questions

What is the CAS number of Proguanil?

The CAS number of Proguanil is 500-92-5.

What are the molecular formula and molecular weight of Proguanil?

Proguanil has molecular formula C11H16ClN5 and molecular weight 253.73100 g/mol.

What are the upstream and downstream products of Proguanil?

For Proguanil, Upstream Products: 1-(4-Chlorophenyl)-3-cyanoguanidine, Isopropylamine, 4-Chloroaniline hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Proguanil (CAS 500-92-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-46089-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.