Mitoguazone

丙脒腙

Also known as: MGBG, Me-GAG, methyl-gag, methylglyoxal bis-(guanylhydrazone), pyruvaldehyde bis(amidinohydrazone), 1,1'-((methylethanediylidene)dinitrilo)diguanidine, 1,1'-((methylethanediylidene)dinitrilo)di-guanidin, 2,2'-(1-methyl-1,2-ethanediylidene)bis(hydrazinecarbimidamide), 2,2'-(1-methyl-1,2-ethanediylidene)bis-hydrazinecarboximidamid, methyl-g, methyl-GAG

Mitoguazone (CAS 459-86-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C5H12N8 and a molecular weight of 184.20200 g/mol. It is also known as MGBG, Me-GAG and methyl-gag. Key properties include a boiling point of 436.6ºC at 760mmHg, a density of 1.55g/cm3 and a flash point of 217.8ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 459-86-9
Jingsj CID: J-1959125-2
Molecular Formula: C₅H₁₂N₈
Chinese Name: 丙脒腙
Molecular Weight: 184.20200 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	436.6ºC at 760mmHg
Density	1.55g/cm3
Flash Point	217.8ºC
Exact Mass	184.11800
PSA	148.52000
LogP	0.69610
Vapor Pressure	7.99E-08mmHg at 25°C
Refractive Index	1.692

Activity & Biological Data

Additional Information	[1]. J Rizzo, et al. Pharmacokinetic Profile of Mitoguazone (MGBG) in Patients With AIDS Related non-Hodgkin's Lymphoma. Invest New Drugs. 1996;14(2):227-34. [2]. K Davidson, et al. Mitoguazone Induces Apoptosis via a p53-independent Mechanism. Anticancer Drugs. 1998 Aug;9(7):635-40. [3]. Xia Jin, et al. Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone. J Virol. 2015 Nov;89(22):11176-89. [4]. A M Levine, et al. Mitoguazone Therapy in Patients With Refractory or Relapsed AIDS-related Lymphoma: Results From a Multicenter Phase II Trial. J Clin Oncol. 1997 Mar;15(3):1094-103. [5]. R Amlacher, et al. Influence of Leukemia P388 on the Pharmacokinetics of Mitoguazone in B6D2F1 Mice. Pharmazie. 1990 May;45(5):364-6.

Additional Information

[1]. J Rizzo, et al. Pharmacokinetic Profile of Mitoguazone (MGBG) in Patients With AIDS Related non-Hodgkin's Lymphoma. Invest New Drugs. 1996;14(2):227-34. [2]. K Davidson, et al. Mitoguazone Induces Apoptosis via a p53-independent Mechanism. Anticancer Drugs. 1998 Aug;9(7):635-40. [3]. Xia Jin, et al. Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone. J Virol. 2015 Nov;89(22):11176-89. [4]. A M Levine, et al. Mitoguazone Therapy in Patients With Refractory or Relapsed AIDS-related Lymphoma: Results From a Multicenter Phase II Trial. J Clin Oncol. 1997 Mar;15(3):1094-103. [5]. R Amlacher, et al. Influence of Leukemia P388 on the Pharmacokinetics of Mitoguazone in B6D2F1 Mice. Pharmazie. 1990 May;45(5):364-6.

Frequently Asked Questions

What is the CAS number of Mitoguazone?

The CAS number of Mitoguazone is 459-86-9.

What are the molecular formula and molecular weight of Mitoguazone?

Mitoguazone has molecular formula C5H12N8 and molecular weight 184.20200 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Mitoguazone (CAS 459-86-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959125-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.