Harmine

Also known as: Harmine, Banisterine, Telepathine, Yageine, Yajeine, Garmin, Harmin, 1-Methyl-7-methoxy-β-carboline, 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole, 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, Banisterine monohydrate, Telepathin, Yagein, Hal base, MFCD00150055, EINECS 207-131-4

Harmine (CAS 442-51-3) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C13H12N2O and a molecular weight of 212.247 g/mol. Key properties include a melting point of 262-264 °C(lit.), a boiling point of 421.4±40.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 139.8±17.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 442-51-3
Jingsj CID: J-2734-6
Molecular Formula: C₁₃H₁₂N₂O
Molecular Weight: 212.247 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	262-264 °C(lit.)
Boiling Point	421.4±40.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	139.8±17.0 °C
Exact Mass	212.094955
PSA	37.91000
LogP	3.17
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.706

Activity & Biological Data

Target	5-HT2A Receptor:397 nM (Ki) DYRK1A RAD51
Additional Information	[1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.

Target

5-HT2A Receptor:397 nM (Ki) DYRK1A RAD51

Additional Information

[1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Harmine?

The CAS number of Harmine is 442-51-3.

What are the molecular formula and molecular weight of Harmine?

Harmine has molecular formula C13H12N2O and molecular weight 212.247 g/mol.

What are the upstream and downstream products of Harmine?

For Harmine, Upstream Products: N,N-Dimethylacetamide, Harmaline, 6-Methoxytryptamine; Downstream Products: Harmol, Harmalol, Harmane.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Harmine (CAS 442-51-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-2734-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.