Harmane

Also known as: 1-Methyl-9H-pyrido[3,4-b]indole, 2-Methyl-β-carboline, 3-Methyl-4-carboline, Aribine, Harman, Locuturine, Loturine, 1-Methyl-β-carboline, 1-Methylnorharman

Harmane (CAS 486-84-0) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C12H10N2 and a molecular weight of 182.221 g/mol. Key properties include a melting point of 235-238 °C(lit.), a boiling point of 386.9±22.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 176.2±13.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 486-84-0
Jingsj CID: J-49708-8
Molecular Formula: C₁₂H₁₀N₂
Molecular Weight: 182.221 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	235-238 °C(lit.)
Boiling Point	386.9±22.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	176.2±13.6 °C
Exact Mass	182.084396
PSA	28.68000
LogP	3.26
Vapor Pressure	0.0±0.8 mmHg at 25°C
Refractive Index	1.750

Activity & Biological Data

Target	hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50)
Additional Information	[1]. Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6. [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30.

Target

hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50)

Additional Information

[1]. Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6. [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Harmane?

The CAS number of Harmane is 486-84-0.

What are the molecular formula and molecular weight of Harmane?

Harmane has molecular formula C12H10N2 and molecular weight 182.221 g/mol.

What are the upstream and downstream products of Harmane?

For Harmane, Upstream Products: tert-Butyl hydroperoxide, Norharmane, N-Acetyltryptamine; Downstream Products: Norharmane, 1-methyl-8-nitro-9H-pyrido[3,4-b]indole, methyl 2-(9H-pyrido[3,4-b]indol-1-yl)acetate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Harmane (CAS 486-84-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49708-8 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.