Diltiazem hydrochloride

Also known as: Diltiazem HCl, (+)-cis-Diltiazem Hydrochloride, Cardizem, Tiazac, Dilthiazem hydrochloride, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride, (2S-cis)-3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride, CRD-401, Altiazem, Anginyl, Angizem, Bruzem, Calcicard, Dilzem, Kardil, Masdil, Zilde, Zilden, Cormax

Diltiazem hydrochloride (CAS 33286-22-5) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C22H27ClN2O4S and a molecular weight of 450.979 g/mol. Key properties include a melting point of 212-214 °C, a boiling point of 594.4ºC at 760mmHg, a density of 1.26g/cm3 and a flash point of 313.3ºC. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H302 — Harmful if swallowed and H312 — Harmful in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 33286-22-5
Jingsj CID: J-44387-8
Molecular Formula: C₂₂H₂₇ClN₂O₄S
Molecular Weight: 450.979 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	212-214 °C
Boiling Point	594.4ºC at 760mmHg
Density	1.26g/cm3
Flash Point	313.3ºC
Exact Mass	450.138000
PSA	84.38000
LogP	4.23550
Refractive Index	118 ° (C=1, H2O)
Additional Property	soluble

GHS Safety & Compliance

Flammable / IrritantSignal word: Danger

H225 — Highly flammable liquid and vapour
H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H332 — Harmful if inhaled
H319 — Causes serious eye irritation

Activity & Biological Data

Additional Information	[1]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. [2]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. [3]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. [4]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. [5]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.

Additional Information

[1]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. [2]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. [3]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. [4]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. [5]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Diltiazem hydrochloride?

The CAS number of Diltiazem hydrochloride is 33286-22-5.

What are the molecular formula and molecular weight of Diltiazem hydrochloride?

Diltiazem hydrochloride has molecular formula C22H27ClN2O4S and molecular weight 450.979 g/mol.

Is Diltiazem hydrochloride hazardous?

Diltiazem hydrochloride has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H302 — Harmful if swallowed; H312 — Harmful in contact with skin.

What are the upstream and downstream products of Diltiazem hydrochloride?

For Diltiazem hydrochloride, Upstream Products: Deacetyldiltiazem, Isopropenyl acetate, 4-Methoxybenzaldehyde; Downstream Products: Diltiazem, Deacetyldiltiazem.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Diltiazem hydrochloride (CAS 33286-22-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-44387-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.