Diltiazem

Also known as: Cardizem, Adizem, CRD 401, (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, (+)-cis-Diltiazem, d-Diltiazem, Diltiazemum, Tildiem, Zilden, Coras, Citizem, Diladel, Dilrene, Deltazen, 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-

Diltiazem (CAS 42399-41-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H26N2O4S and a molecular weight of 414.518 g/mol. Key properties include a melting point of 104-106°C (lit.), a boiling point of 594.4±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 313.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 42399-41-7
Jingsj CID: J-1955293-3
Molecular Formula: C₂₂H₂₆N₂O₄S
Molecular Weight: 414.518 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	104-106°C (lit.)
Boiling Point	594.4±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	313.3±30.1 °C
Exact Mass	414.161316
PSA	84.38000
LogP	3.63
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.621
Storage Conditions	20°C

Activity & Biological Data

Target	L-type Ca2+ channel[1]
Additional Information	[1]. Yoshinari Niimi, et al. Diltiazem facilitates inactivation of single L-type calcium channels in guinea pig ventricular myocytes. Jpn Heart J. 2003 Nov;44(6):1005-14. [2]. S Lin Tang, et l. Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel. Mol Pharmacol. 2019 Oct; 96(4): 485–492. [3]. Anja Mieth , et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. [4]. S. J. Downing, et al. Diltiazem pharmacokinetics in the rat and relationship between its serum concentration and uterine and cardiovascular effects. Br J Pharmacol. 1987 Aug; 91(4): 735–745.

Target

L-type Ca2+ channel[1]

Additional Information

[1]. Yoshinari Niimi, et al. Diltiazem facilitates inactivation of single L-type calcium channels in guinea pig ventricular myocytes. Jpn Heart J. 2003 Nov;44(6):1005-14. [2]. S Lin Tang, et l. Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel. Mol Pharmacol. 2019 Oct; 96(4): 485–492. [3]. Anja Mieth , et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. [4]. S. J. Downing, et al. Diltiazem pharmacokinetics in the rat and relationship between its serum concentration and uterine and cardiovascular effects. Br J Pharmacol. 1987 Aug; 91(4): 735–745.

Frequently Asked Questions

What is the CAS number of Diltiazem?

The CAS number of Diltiazem is 42399-41-7.

What are the molecular formula and molecular weight of Diltiazem?

Diltiazem has molecular formula C22H26N2O4S and molecular weight 414.518 g/mol.

What are the upstream and downstream products of Diltiazem?

For Diltiazem, Upstream Products: Deacetyldiltiazem, 2-Dimethylaminoethyl chloride hydrochloride, Diltiazem hydrochloride; Downstream Products: Deacetyldiltiazem, Deacetyl-O-demethyldiltiazem.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Diltiazem (CAS 42399-41-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955293-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.