O6-Benzylguanine

O6-苄基鸟嘌呤

Also known as: 6-O-Benzylguanine, 2-Amino-6-(benzyloxy)-9H-purine, 2-Amino-6-(benzyloxy)purine, 6-(Benzyloxy)-7H-purin-2-amine, 6-(Phenylmethoxy)-9H-purin-2-amine, 6-Benzyloxyguanine, NSC 637037

O6-Benzylguanine (CAS 19916-73-5) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C12H11N5O and a molecular weight of 241.249 g/mol. It is also known as 6-O-Benzylguanine, 2-Amino-6-(benzyloxy)-9H-purine and 2-Amino-6-(benzyloxy)purine. Key properties include a melting point of 193(dec.), a boiling point of 621.4±63.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 329.6±33.7 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 19916-73-5
Jingsj CID: J-1130858-6
Molecular Formula: C₁₂H₁₁N₅O
Chinese Name: O6-苄基鸟嘌呤
Molecular Weight: 241.249 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	193(dec.)
Boiling Point	621.4±63.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	329.6±33.7 °C
Exact Mass	241.096359
PSA	89.71000
LogP	1.95
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.743
Additional Property	methanol: 20 mg/mL

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Rabik CA, Njoku MC, Dolan ME. Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer Treat Rev. 2006;32(4):261‐276. [2]. Konduri, Santhi D et al. Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 15,19 (2009): 6087-95.

Additional Information

[1]. Rabik CA, Njoku MC, Dolan ME. Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer Treat Rev. 2006;32(4):261‐276. [2]. Konduri, Santhi D et al. Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 15,19 (2009): 6087-95.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of O6-Benzylguanine?

The CAS number of O6-Benzylguanine is 19916-73-5.

What are the molecular formula and molecular weight of O6-Benzylguanine?

O6-Benzylguanine has molecular formula C12H11N5O and molecular weight 241.249 g/mol.

Is O6-Benzylguanine hazardous?

O6-Benzylguanine has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of O6-Benzylguanine?

For O6-Benzylguanine, Upstream Products: 2-Amino-6-chloropurine, Benzyl alcohol, Sodium benzyloxide; Downstream Products: Benzyl phenyl sulfide, Guanine, (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "O6-Benzylguanine (CAS 19916-73-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1130858-6 (accessed 2026-10-29).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.