Loxapine

洛沙平

Also known as: 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine, 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine, Cloxazepine, Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, Loxapin, Loxapina, Loxapinum, Loxitane, Oxilapine

Loxapine (CAS 1977-10-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H18ClN3O and a molecular weight of 327.80800 g/mol. It is also known as 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine, 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine and Cloxazepine. Key properties include a melting point of 109-110° and a density of 1.2299 (rough estimate). No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1977-10-2
Jingsj CID: J-1968954-2
Molecular Formula: C₁₈H₁₈ClN₃O
Chinese Name: 洛沙平
Molecular Weight: 327.80800 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	109-110°
Density	1.2299 (rough estimate)
Exact Mass	327.11400
PSA	28.07000
LogP	3.08280
Vapor Pressure	1.36E-08mmHg at 25°C
Refractive Index	1.5800 (estimate)
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. [2]. Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. [3]. Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85. [4]. Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4.

Additional Information

[1]. Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. [2]. Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. [3]. Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85. [4]. Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4.

Frequently Asked Questions

What is the CAS number of Loxapine?

The CAS number of Loxapine is 1977-10-2.

What are the molecular formula and molecular weight of Loxapine?

Loxapine has molecular formula C18H18ClN3O and molecular weight 327.80800 g/mol.

What are the upstream and downstream products of Loxapine?

For Loxapine, Upstream Products: 1-Methylpiperazine; Downstream Products: 2-Chlorodibenzo[b,f][1,4]oxazepin-11(10H)-one, Amoxapine.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Loxapine (CAS 1977-10-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1968954-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.