Tacrine hydrochloride

Also known as: Tacrine HCl, 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride, 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride, Cognex, THA, 1,2,3,4-Tetrahydroacridin-9-amine hydrochloride (1:1), 1,2,3,4-tetrahydro-9-aminoacridine hydrochloride, 1,2,3,4-tetrahydro-9-acridinamine monohydrochloride

Tacrine hydrochloride (CAS 1684-40-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C13H15ClN2 and a molecular weight of 234.73000 g/mol. Key properties include a melting point of 280-284 °C(lit.), a boiling point of 409.4ºC at 760mmHg and a flash point of 230.5ºC. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.: 1684-40-8
Jingsj CID: J-28132-3
Molecular Formula: C₁₃H₁₅ClN₂
Molecular Weight: 234.73000 g/mol
Category: Organic Acids
Last updated: 11/2/2026

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Physicochemical Properties

Melting Point	280-284 °C(lit.)
Boiling Point	409.4ºC at 760mmHg
Flash Point	230.5ºC
Exact Mass	270.113495
PSA	38.91000
LogP	4.07900
Vapor Pressure	6.49E-07mmHg at 25°C

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]
Additional Information	[1]. Ahmed M, et, al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25; 162(2):165-71.c [2]. Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62. [3]. The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Yi YM, et, al. Int J Ophthalmol. 2015 Oct 18; 8(5): 884-90.

Target

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]

Additional Information

[1]. Ahmed M, et, al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25; 162(2):165-71.c [2]. Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62. [3]. The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Yi YM, et, al. Int J Ophthalmol. 2015 Oct 18; 8(5): 884-90.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Tacrine hydrochloride?

The CAS number of Tacrine hydrochloride is 1684-40-8.

What are the molecular formula and molecular weight of Tacrine hydrochloride?

Tacrine hydrochloride has molecular formula C13H15ClN2 and molecular weight 234.73000 g/mol.

Is Tacrine hydrochloride hazardous?

Tacrine hydrochloride has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Tacrine hydrochloride?

For Tacrine hydrochloride, Upstream Products: Tacrine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/2/2026

How to cite: Jingsj. "Tacrine hydrochloride (CAS 1684-40-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28132-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.