Tacrine

Also known as: 1,2,3,4-tetrahydroacridin-9-amine, 9-amino-1,2,3,4-tetrahydroacridine, Tetrahydroaminacrine, Tetrahydroaminoacridine, THA, Cognex, Tenakrin, Romotal

Tacrine (CAS 321-64-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H14N2 and a molecular weight of 198.264 g/mol. Key properties include a melting point of 283-284ºC, a boiling point of 353.8±42.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 167.8±27.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 321-64-2
Jingsj CID: J-1330696-2
Molecular Formula: C₁₃H₁₄N₂
Molecular Weight: 198.264 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	283-284ºC
Boiling Point	353.8±42.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	167.8±27.9 °C
Exact Mass	198.115692
PSA	38.91000
LogP	1.78
Vapor Pressure	0.0±0.8 mmHg at 25°C
Refractive Index	1.682

Activity & Biological Data

Target	IC50: 109 nM (AChE)[3]
Additional Information	[1]. Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9(4):332-335. [2]. Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7(23):20321-20331. Published 2022 Jun 2. [3]. Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23(7):1916-1922.

Target

IC50: 109 nM (AChE)[3]

Additional Information

[1]. Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9(4):332-335. [2]. Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7(23):20321-20331. Published 2022 Jun 2. [3]. Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23(7):1916-1922.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Tacrine?

The CAS number of Tacrine is 321-64-2.

What are the molecular formula and molecular weight of Tacrine?

Tacrine has molecular formula C13H14N2 and molecular weight 198.264 g/mol.

What are the upstream and downstream products of Tacrine?

For Tacrine, Upstream Products: Cyclohexanone, 2-Aminobenzonitrile, 9-Chloro-1,2,3,4-tetrahydroacridine; Downstream Products: 9-Chloro-1,2,3,4-tetrahydroacridine, Bucricaine, Tacrine hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tacrine (CAS 321-64-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1330696-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.