Phorbol 12-myristate 13-acetate

佛波醇12-十四酸酯13-乙酸酯

Also known as: 12-O-Tetradecanoylphorbol 13-acetate, 12-O-tetradecanoylphorbol-13-acetate, PMA, TPA, 4β-Phorbol 12-myristate 13-acetate, Phorbol 12-myristate 13-acetate (PMA), 12-Myristate 13-acetate phorbol

Phorbol 12-myristate 13-acetate (CAS 16561-29-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C36H56O8 and a molecular weight of 616.825 g/mol. It is also known as 12-O-Tetradecanoylphorbol 13-acetate, 12-O-tetradecanoylphorbol-13-acetate and PMA. Key properties include a boiling point of 698.1±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 208.1±25.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 16561-29-8
Jingsj CID: J-27341-7
Molecular Formula: C₃₆H₅₆O₈
Chinese Name: 佛波醇12-十四酸酯13-乙酸酯
Molecular Weight: 616.825 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	698.1±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	208.1±25.0 °C
Exact Mass	616.397522
PSA	130.36000
LogP	7.71
Vapor Pressure	0.0±5.0 mmHg at 25°C
Refractive Index	1.553
Additional Property	DMSO: DMSO solutions can be stored dark at −20?#x00b0;C for at least six months.soluble

Activity & Biological Data

Target	PKC:11.7 nM (EC50)
Additional Information	[1]. Xu F, et al. Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4. Br J Pharmacol. 2003 Sep;140(2):413-21. [2]. Mugami S, et al. Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. Mol Cell Endocrinol. 2017 Jan 5;439:141-154. [3]. Hou S, et al. Mechanism of Mitochondrial Connexin43's Protection of the Neurovascular Unit under Acute Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci. 2016 May 5;17(5). pii: E679. [4]. Zhang T, et al. MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors. Front Mol Neurosci. 2017 Aug 7;10:247.

Target

PKC:11.7 nM (EC50)

Additional Information

[1]. Xu F, et al. Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4. Br J Pharmacol. 2003 Sep;140(2):413-21. [2]. Mugami S, et al. Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. Mol Cell Endocrinol. 2017 Jan 5;439:141-154. [3]. Hou S, et al. Mechanism of Mitochondrial Connexin43's Protection of the Neurovascular Unit under Acute Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci. 2016 May 5;17(5). pii: E679. [4]. Zhang T, et al. MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors. Front Mol Neurosci. 2017 Aug 7;10:247.

Frequently Asked Questions

What is the CAS number of Phorbol 12-myristate 13-acetate?

The CAS number of Phorbol 12-myristate 13-acetate is 16561-29-8.

What are the molecular formula and molecular weight of Phorbol 12-myristate 13-acetate?

Phorbol 12-myristate 13-acetate has molecular formula C36H56O8 and molecular weight 616.825 g/mol.

What are the upstream and downstream products of Phorbol 12-myristate 13-acetate?

For Phorbol 12-myristate 13-acetate, Upstream Products: Phorbol, Myristoyl chloride.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Phorbol 12-myristate 13-acetate (CAS 16561-29-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-27341-7 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.