Pyripyropene A

啶南平A

Also known as: FO 1289A, (+)-Pyripyropene A, 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-, (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-

Pyripyropene A (CAS 147444-03-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C31H37NO10 and a molecular weight of 583.626 g/mol. It is also known as FO 1289A, (+)-Pyripyropene A and 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-, (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-. Key properties include a melting point of 153-154°C (lit.), a boiling point of 690.8±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 371.6±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 147444-03-9
Jingsj CID: J-1981143-7
Molecular Formula: C₃₁H₃₇NO₁₀
Chinese Name: 啶南平A
Molecular Weight: 583.626 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	153-154°C (lit.)
Boiling Point	690.8±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	371.6±31.5 °C
Exact Mass	583.241760
PSA	151.46000
LogP	2.68
Vapor Pressure	0.0±2.3 mmHg at 25°C
Refractive Index	1.587

Activity & Biological Data

Target	IC50: 0.07 µM (ACAT2)[1]
Additional Information	[1]. Hayashi A, et al. Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells. Biol Pharm Bull. 2009 Jul;32(7):1261-5. [2]. Ohtawa M, et al. Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors. ChemMedChem. 2018 Mar 6;13(5):411-421. [3]. Ohshiro T, et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. [4]. Lee KR , et al. Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies. Biomed Chromatogr. 2019 Feb;33(2):e4388.

Target

IC50: 0.07 µM (ACAT2)[1]

Additional Information

[1]. Hayashi A, et al. Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells. Biol Pharm Bull. 2009 Jul;32(7):1261-5. [2]. Ohtawa M, et al. Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors. ChemMedChem. 2018 Mar 6;13(5):411-421. [3]. Ohshiro T, et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. [4]. Lee KR , et al. Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies. Biomed Chromatogr. 2019 Feb;33(2):e4388.

Frequently Asked Questions

What is the CAS number of Pyripyropene A?

The CAS number of Pyripyropene A is 147444-03-9.

What are the molecular formula and molecular weight of Pyripyropene A?

Pyripyropene A has molecular formula C31H37NO10 and molecular weight 583.626 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Pyripyropene A (CAS 147444-03-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981143-7 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.