Buclizine dihydrochloride

盐酸安其敏

Also known as: Buclizine, dihydrochloride, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride, 1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine dihydrochloride, Posdel, Buclina, Longifene, Vibazine, UCB-4445, Softran, Aphilanr, Postafen

Buclizine dihydrochloride (CAS 129-74-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C28H35Cl3N2 and a molecular weight of 505.950 g/mol. It is also known as Buclizine, dihydrochloride, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride and 1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine dihydrochloride. Key properties include a melting point of 230-240ºC, a boiling point of 520.1ºC at 760 mmHg and a flash point of 268.3ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 129-74-8
Jingsj CID: J-1972898-4
Molecular Formula: C₂₈H₃₅Cl₃N₂
Chinese Name: 盐酸安其敏
Molecular Weight: 505.950 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	230-240ºC
Boiling Point	520.1ºC at 760 mmHg
Flash Point	268.3ºC
Exact Mass	504.186584
PSA	6.48000
LogP	8.02450
Vapor Pressure	6.44E-11mmHg at 25°C

Activity & Biological Data

Additional Information	[1]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11. [2]. Nawab Sher, et al. Simultaneous determination of antihistamine anti-allergic drugs, cetirizine, domperidone, chlorphenamine maleate, loratadine, meclizine and buclizine in pharmaceutical formulations, human serum and pharmacokinetics application. Analytical methods • March 2014. [3]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget . 2016 Mar 29;7(13):16818-39.

Additional Information

[1]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11. [2]. Nawab Sher, et al. Simultaneous determination of antihistamine anti-allergic drugs, cetirizine, domperidone, chlorphenamine maleate, loratadine, meclizine and buclizine in pharmaceutical formulations, human serum and pharmacokinetics application. Analytical methods • March 2014. [3]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget . 2016 Mar 29;7(13):16818-39.

Frequently Asked Questions

What is the CAS number of Buclizine dihydrochloride?

The CAS number of Buclizine dihydrochloride is 129-74-8.

What are the molecular formula and molecular weight of Buclizine dihydrochloride?

Buclizine dihydrochloride has molecular formula C28H35Cl3N2 and molecular weight 505.950 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Buclizine dihydrochloride (CAS 129-74-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1972898-4 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.