CP-466722

1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺

Also known as: CP466722, 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine, HMS3265A19, HMS3265A20, HMS3265B19, S2245_Selleck, cc-85

CP-466722 (CAS 1080622-86-1) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C17H15N7O2 and a molecular weight of 349.347 g/mol. It is also known as CP466722, 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine and 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine. Key properties include a boiling point of 642.3±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 342.2±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1080622-86-1
Jingsj CID: J-1957536-6
Molecular Formula: C₁₇H₁₅N₇O₂
Chinese Name: 1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺
Molecular Weight: 349.347 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	642.3±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	342.2±34.3 °C
Exact Mass	349.128723
PSA	114.59000
LogP	0.83
Appearance	white to beige
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.737
Storage Conditions	2-8°C
Additional Property	DMSO: soluble0.5mg/mL, clear (warmed)

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	ATM:4.1 μM (IC50)
Additional Information	[1]. Rainey MD, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74. [2]. Guo K, et al. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19(4):538-46. [3]. Węsierska-Gądek J, et al. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. J Cancer Prev. 2014 Jun;19(2):125-36.

Target

ATM:4.1 μM (IC50)

Additional Information

[1]. Rainey MD, et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74. [2]. Guo K, et al. Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19(4):538-46. [3]. Węsierska-Gądek J, et al. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. J Cancer Prev. 2014 Jun;19(2):125-36.

Frequently Asked Questions

What is the CAS number of CP-466722?

The CAS number of CP-466722 is 1080622-86-1.

What are the molecular formula and molecular weight of CP-466722?

CP-466722 has molecular formula C17H15N7O2 and molecular weight 349.347 g/mol.

Is CP-466722 hazardous?

CP-466722 has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "CP-466722 (CAS 1080622-86-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957536-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.