Fadrozole hydrochloride

盐酸法倔唑

Also known as: CGS-16949A, CGS 16949A, Fadrazole, Fadrozole HCl, 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride, 4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-a]PYRIDIN-5-YL)BENZONITRILE HYDROCHLORIDE, D02451, MFCD00866239

Fadrozole hydrochloride (CAS 102676-31-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C14H14ClN3 and a molecular weight of 259.73400 g/mol. It is also known as CGS-16949A, CGS 16949A and Fadrazole. Key properties include a boiling point of 481.7ºC at 760mmHg and a flash point of 245.1ºC. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H361 — Suspected of damaging fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 102676-31-3
Jingsj CID: J-28239-4
Molecular Formula: C₁₄H₁₄ClN₃
Chinese Name: 盐酸法倔唑
Molecular Weight: 259.73400 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	481.7ºC at 760mmHg
Flash Point	245.1ºC
Exact Mass	259.08800
PSA	41.61000
LogP	3.48248
Vapor Pressure	1.95E-09mmHg at 25°C

GHS Safety & Compliance

Acute Toxicity / Health HazardSignal word: Danger

H301 — Toxic if swallowed
H361 — Suspected of damaging fertility or the unborn child

Activity & Biological Data

Target	IC50: 6.4 nM (aromatase)[1]
Additional Information	[1]. Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36. [2]. Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72(1):72-5. [3]. Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32(11):1379-87.

Target

IC50: 6.4 nM (aromatase)[1]

Additional Information

[1]. Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36. [2]. Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72(1):72-5. [3]. Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32(11):1379-87.

Frequently Asked Questions

What is the CAS number of Fadrozole hydrochloride?

The CAS number of Fadrozole hydrochloride is 102676-31-3.

What are the molecular formula and molecular weight of Fadrozole hydrochloride?

Fadrozole hydrochloride has molecular formula C14H14ClN3 and molecular weight 259.73400 g/mol.

Is Fadrozole hydrochloride hazardous?

Fadrozole hydrochloride has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H361 — Suspected of damaging fertility or the unborn child.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Fadrozole hydrochloride (CAS 102676-31-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28239-4 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.