Doxepin

Also known as: 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin, 3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, 1-Propanamine, 3-dibenzb,eoxepin-11(6H)-ylidene-N,N-dimethyl-, Quitaxon, Adapin, Sinequan, Aponal, Curatin, Docepin, Doxepine

Doxepin (CAS 1668-19-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H21NO and a molecular weight of 279.37600 g/mol. Key properties include a melting point of 187-189ºC, a boiling point of 413.3ºC at 760 mmHg, a density of 1.122 g/cm3 and a flash point of 121.3ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1668-19-5
Jingsj CID: J-49742-7
Molecular Formula: C₁₉H₂₁NO
Molecular Weight: 279.37600 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	187-189ºC
Boiling Point	413.3ºC at 760 mmHg
Density	1.122 g/cm3
Flash Point	121.3ºC
Exact Mass	279.16200
PSA	12.47000
LogP	3.96240
Vapor Pressure	4.87E-07mmHg at 25°C
Refractive Index	1.5000 (estimate)
Storage Conditions	Store at RT

Activity & Biological Data

Additional Information	[1]. AnnemiekVermeeren, et al. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011): 89-103. [2]. G Hajak, et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001): 453-63. [3]. Mahsa Gharzi, et al. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013. [4]. Jimei Bu, et al. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20(9):1044-1049.

Additional Information

[1]. AnnemiekVermeeren, et al. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011): 89-103. [2]. G Hajak, et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001): 453-63. [3]. Mahsa Gharzi, et al. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013. [4]. Jimei Bu, et al. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20(9):1044-1049.

Customs & Trade Information

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Doxepin?

The CAS number of Doxepin is 1668-19-5.

What are the molecular formula and molecular weight of Doxepin?

Doxepin has molecular formula C19H21NO and molecular weight 279.37600 g/mol.

What are the upstream and downstream products of Doxepin?

For Doxepin, Upstream Products: Dimethylamine, Doxepin hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Doxepin (CAS 1668-19-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49742-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.