Amitriptyline Hydrochloride

Also known as: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride, 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride, 10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine hydrochloride, 5-(3-Dimethylaminopropylidene)dibenzo[a,d][1,4]cycloheptadiene hydrochloride, Amitriptyline HCl

Amitriptyline Hydrochloride (CAS 549-18-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C20H24ClN and a molecular weight of 313.864 g/mol. Key properties include a melting point of 196-197°C, a boiling point of 398.2ºC at 760 mmHg, a density of 1.076g/cm3 and a flash point of 11 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 549-18-8
Jingsj CID: J-48480-0
Molecular Formula: C₂₀H₂₄ClN
Molecular Weight: 313.864 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	196-197°C
Boiling Point	398.2ºC at 760 mmHg
Density	1.076g/cm3
Flash Point	11 °C
Exact Mass	313.159729
PSA	3.24000
LogP	4.97060
Storage Conditions	2-8°C
Additional Property	H2O: soluble

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H370 — Causes damage to organs

Activity & Biological Data

Additional Information	[1]. Tatsumi, M., et al., Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, 1997. 340(2-3): p. 249-58. [2]. http://en.wikipedia.org/wiki/Amitriptyline [3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.

Additional Information

[1]. Tatsumi, M., et al., Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, 1997. 340(2-3): p. 249-58. [2]. http://en.wikipedia.org/wiki/Amitriptyline [3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.

Frequently Asked Questions

What is the CAS number of Amitriptyline Hydrochloride?

The CAS number of Amitriptyline Hydrochloride is 549-18-8.

What are the molecular formula and molecular weight of Amitriptyline Hydrochloride?

Amitriptyline Hydrochloride has molecular formula C20H24ClN and molecular weight 313.864 g/mol.

Is Amitriptyline Hydrochloride hazardous?

Amitriptyline Hydrochloride has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

What are the upstream and downstream products of Amitriptyline Hydrochloride?

For Amitriptyline Hydrochloride, Upstream Products: 5-(3-dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol, Amitriptyline, Dibenzosuberone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Amitriptyline Hydrochloride (CAS 549-18-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-48480-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.