Entacapone

Also known as: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide, (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide, (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide, (E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide, (E)-α-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide, 2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide, Comtan, Comtes, Comtess, OR-611

Entacapone (CAS 130929-57-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H15N3O5 and a molecular weight of 305.286 g/mol. Key properties include a melting point of 162-1630C, a boiling point of 526.6±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 272.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 130929-57-6
Jingsj CID: J-47528-5
Molecular Formula: C₁₄H₁₅N₃O₅
Molecular Weight: 305.286 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	162-1630C
Boiling Point	526.6±50.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	272.3±30.1 °C
Exact Mass	305.101166
PSA	130.38000
LogP	2.38
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.642
Storage Conditions	-20°C Freezer

Activity & Biological Data

Additional Information	[1]. Piccini P, Brooks DJ, Korpela K, The catechol-O-methyltransferase(COMT) inhibitor entacapone enhances the pharmacokinetic and clinical response to Sinemet CR in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2000 May;68(5):589-94. [2]. Di Giovanni S, Eleuteri S, Paleologou KE, Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):1494 [3]. Sethi KD, Hauser RA, Isaacson SH, Levodopa/carbidopa/entacapone 200/50/200 mg (Stalevo 200) in the treatment of Parkinson's disease: a case series. Cases J. 2009 Jul 30;2:7134. [4]. Poulopoulos M, Waters C. Carbidopa/levodopa/entacapone: the evidence for its place in the treatment of Parkinson's disease. Core Evid. 2010 Jul 27;5:1-10.

Additional Information

[1]. Piccini P, Brooks DJ, Korpela K, The catechol-O-methyltransferase(COMT) inhibitor entacapone enhances the pharmacokinetic and clinical response to Sinemet CR in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2000 May;68(5):589-94. [2]. Di Giovanni S, Eleuteri S, Paleologou KE, Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):1494 [3]. Sethi KD, Hauser RA, Isaacson SH, Levodopa/carbidopa/entacapone 200/50/200 mg (Stalevo 200) in the treatment of Parkinson's disease: a case series. Cases J. 2009 Jul 30;2:7134. [4]. Poulopoulos M, Waters C. Carbidopa/levodopa/entacapone: the evidence for its place in the treatment of Parkinson's disease. Core Evid. 2010 Jul 27;5:1-10.

Customs & Trade Information

HS Code	2942000000

Frequently Asked Questions

What is the CAS number of Entacapone?

The CAS number of Entacapone is 130929-57-6.

What are the molecular formula and molecular weight of Entacapone?

Entacapone has molecular formula C14H15N3O5 and molecular weight 305.286 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Entacapone (CAS 130929-57-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-47528-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.