Isonipecotic acid
Also known as: Piperidine-4-carboxylic acid, 4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid, 4-Hexahydroisonicotinic acid, EINECS 207-872-3, MFCD00006004
Isonipecotic acid (CAS 498-94-2) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C6H11NO2 and a molecular weight of 129.157 g/mol. Key properties include a melting point of >300 °C(lit.), a boiling point of 265.8±33.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 114.5±25.4 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.
- CAS No.
- 498-94-2
- Jingsj CID
- J-45292-6
- Molecular Formula
- C6H11NO2
- Molecular Weight
- 129.157 g/mol
- Category
- Pharma Intermediates
- Last updated
- 11/3/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | >300 °C(lit.) |
|---|---|
| Boiling Point | 265.8±33.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 114.5±25.4 °C |
| Exact Mass | 129.078979 |
| PSA | 49.33000 |
| LogP | -0.08 |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| Refractive Index | 1.479 |
| Additional Property | soluble |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | GABAA Receptor[1] |
|---|---|
| Additional Information | [1]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5. [2]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan;44(1):68-75. |
Customs & Trade Information
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Isonipecotic acid?
The CAS number of Isonipecotic acid is 498-94-2.
What are the molecular formula and molecular weight of Isonipecotic acid?
Isonipecotic acid has molecular formula C6H11NO2 and molecular weight 129.157 g/mol.
Is Isonipecotic acid hazardous?
Isonipecotic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of Isonipecotic acid?
For Isonipecotic acid, Upstream Products: Isonicotinic Acid N-Oxide, Isonicotinic acid, 3-Quinuclidinone; Downstream Products: N-Benzylpiperidine-4-carboxamide, 1-Methylpiperidine-4-carboxylic acid hydrochloride, 1-Methylpiperidine-4-carbaldehyde.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Isonipecotic acid (CAS 498-94-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45292-6 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.