Norethindrone

Also known as: Norethisterone, NET, 17α-Ethynyl-19-nortestosterone, 17α-Ethynyl-17β-hydroxy-19-norandrost-4-en-3-one, 19-Nor-17α-ethynyltestosterone, 17β-Hydroxy-19-norpregn-4-en-20-yn-3-one, Ethinylnortestosterone, Primolut N, Noriday, Utovlan

Norethindrone (CAS 68-22-4) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C20H26O2 and a molecular weight of 298.419 g/mol. Key properties include a melting point of 205-206 °C(lit.), a boiling point of 447.0±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 190.5±21.3 °C. It is classified under GHS with signal word Warning and hazard statements H351 — Suspected of causing cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 68-22-4
Jingsj CID: J-4497-4
Molecular Formula: C₂₀H₂₆O₂
Molecular Weight: 298.419 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	205-206 °C(lit.)
Boiling Point	447.0±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	190.5±21.3 °C
Exact Mass	298.193268
PSA	37.30000
LogP	3.38
Vapor Pressure	0.0±2.5 mmHg at 25°C
Refractive Index	1.577
Additional Property	chloroform: ≥50 mg/mL, clear, colorless

GHS Safety & Compliance

Health HazardSignal word: Warning

H351 — Suspected of causing cancer

Activity & Biological Data

Target	Progesterone Receptor[1]
Additional Information	[1]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. [2]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. [3]. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. [4]. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8.

Target

Progesterone Receptor[1]

Additional Information

[1]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. [2]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. [3]. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. [4]. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8.

Customs & Trade Information

HS Code	2937290090

Frequently Asked Questions

What is the CAS number of Norethindrone?

The CAS number of Norethindrone is 68-22-4.

What are the molecular formula and molecular weight of Norethindrone?

Norethindrone has molecular formula C20H26O2 and molecular weight 298.419 g/mol.

Is Norethindrone hazardous?

Norethindrone has GHS signal word Warning and hazard statements H351 — Suspected of causing cancer.

What are the upstream and downstream products of Norethindrone?

For Norethindrone, Upstream Products: Norethynodrel, Nandrolone, 19-Nor-4-androstene-3,17-dione; Downstream Products: Lynestrenol, Norethandrolone, Ethinyl estradiol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Norethindrone (CAS 68-22-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-4497-4 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.