Rosiglitazone
Also known as: BRL 49653, Avandia, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione, MFCD00871760, 5-(4-[2-(Methyl(pyridin-2-yl)amino)ethoxy]benzyl)thiazolidine-2,4-dione
Rosiglitazone (CAS 122320-73-4) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C18H19N3O3S and a molecular weight of 357.427 g/mol. Key properties include a melting point of 153-155ºC, a boiling point of 585.0±35.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 307.6±25.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 122320-73-4
- Jingsj CID
- J-43216-6
- Molecular Formula
- C18H19N3O3S
- Molecular Weight
- 357.427 g/mol
- Category
- Ketones
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 153-155ºC |
|---|---|
| Boiling Point | 585.0±35.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 307.6±25.9 °C |
| Exact Mass | 357.114716 |
| PSA | 96.83000 |
| LogP | 2.56 |
| Vapor Pressure | 0.0±1.6 mmHg at 25°C |
| Refractive Index | 1.642 |
| Storage Conditions | 2-8°C |
Activity & Biological Data
| Target | PPARγ1:30 nM (EC50) PPARγ2:100 nM (EC50) |
|---|---|
| Additional Information | [1]. Lehmann JM, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2;270(22):12953-6. [2]. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996 Feb 2;39(3):665-8. [3]. Thouennon E, et al. Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J Neurochem. 2015 Aug;134(3):463-70. [4]. Majeed Y, et al. Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Mol Pharmacol. 2011 Jun;79(6):1023-30. [5]. Ateyya H, et al. Beneficial effects of rosiglitazone and losartan combination in diabetic rats. Can J Physiol Pharmacol. 2018 Mar;96(3):215-220. |
Customs & Trade Information
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Rosiglitazone?
The CAS number of Rosiglitazone is 122320-73-4.
What are the molecular formula and molecular weight of Rosiglitazone?
Rosiglitazone has molecular formula C18H19N3O3S and molecular weight 357.427 g/mol.
What are the upstream and downstream products of Rosiglitazone?
For Rosiglitazone, Upstream Products: 5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]benzylidene]-2,4-thiazolidinedione, Pioglitazone hydrochloride, 2,4-Thiazolidinedione; Downstream Products: Rosiglitazone maleate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Rosiglitazone (CAS 122320-73-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-43216-6 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.