4-Methyldaphnetin

Also known as: 7,8-Dihydroxy-4-methylcoumarin, 4-Methyl-7,8-dihydroxycoumarin, 7,8-Dihydroxy-4-methyl-2H-chromen-2-one, 7,8-Dihydroxy-4-methyl-2H-1-benzopyran-2-one, 4-Methyldaphnetine, NSC 45795, NSC 72276, Coumarin,7,8-dihydroxy-4-methyl, EINECS 218-290-4, MFCD00016972

4-Methyldaphnetin (CAS 2107-77-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H8O4 and a molecular weight of 192.168 g/mol. Key properties include a melting point of 242-246 °C(lit.), a boiling point of 421.5±45.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 176.0±22.2 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 2107-77-9
Jingsj CID: J-35100-8
Molecular Formula: C₁₀H₈O₄
Molecular Weight: 192.168 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	242-246 °C(lit.)
Boiling Point	421.5±45.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	176.0±22.2 °C
Exact Mass	192.042252
PSA	70.67000
LogP	1.95
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.652

Activity & Biological Data

Additional Information	[1]. Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21. [2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4.

Additional Information

[1]. Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21. [2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4.

Customs & Trade Information

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 4-Methyldaphnetin?

The CAS number of 4-Methyldaphnetin is 2107-77-9.

What are the molecular formula and molecular weight of 4-Methyldaphnetin?

4-Methyldaphnetin has molecular formula C10H8O4 and molecular weight 192.168 g/mol.

What are the upstream and downstream products of 4-Methyldaphnetin?

For 4-Methyldaphnetin, Upstream Products: Ethyl acetoacetate, Pyrogallol, Methyl acetoacetate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Methyldaphnetin (CAS 2107-77-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-35100-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.