Magnolol

Also known as: 2,2'-Bichavicol, 2,2'-Dihydroxy-5,5'-diallylbiphenyl, 5,5'-Diallyl-2,2'-biphenyldiol, 5,5'-Diallyl-2,2'-dihydroxybiphenyl, 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol, 5,5'-Di-2-propenyl-[1,1'-biphenyl]-2,2'-diol, 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol

Magnolol (CAS 528-43-8) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C18H18O2 and a molecular weight of 266.334 g/mol. Key properties include a melting point of 99 - 101ºC, a boiling point of 401.0±40.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 184.5±21.9 °C. It is classified under GHS with signal word Danger and hazard statements H315 — Causes skin irritation, H318 — Causes serious eye damage and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 528-43-8
Jingsj CID: J-3385-9
Molecular Formula: C₁₈H₁₈O₂
Molecular Weight: 266.334 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	99 - 101ºC
Boiling Point	401.0±40.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	184.5±21.9 °C
Exact Mass	266.130676
PSA	40.46000
LogP	3.94
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.602

GHS Safety & Compliance

Corrosion / Irritant / Environmental HazardSignal word: Danger

H315 — Causes skin irritation
H318 — Causes serious eye damage
H335 — May cause respiratory irritation
H411 — Toxic to aquatic life with long lasting effects

Activity & Biological Data

Target	RXRα:10.4 μM (EC50) PPARγ:17.7 μM (EC50)
Additional Information	[1]. Zhang H, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6(11):e28253. [2]. Choi SS, et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14. [3]. Zhao L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22(7). pii: E1218.

Target

RXRα:10.4 μM (EC50) PPARγ:17.7 μM (EC50)

Additional Information

[1]. Zhang H, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6(11):e28253. [2]. Choi SS, et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14. [3]. Zhao L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22(7). pii: E1218.

Customs & Trade Information

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Frequently Asked Questions

What is the CAS number of Magnolol?

The CAS number of Magnolol is 528-43-8.

What are the molecular formula and molecular weight of Magnolol?

Magnolol has molecular formula C18H18O2 and molecular weight 266.334 g/mol.

Is Magnolol hazardous?

Magnolol has GHS signal word Danger and hazard statements H315 — Causes skin irritation; H318 — Causes serious eye damage; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Magnolol?

For Magnolol, Upstream Products: 4-Allylphenol, Estragole, 4-Bromophenol; Downstream Products: 2,2'-Biphenol, Dibenzo[b,d]furan, Tetrahydromagnolol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Magnolol (CAS 528-43-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-3385-9 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.