Etodolac

Also known as: 1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, Lodine, Ultradol, Zedolac, Etodolic acid, etodolacum, Edolan, Etopen, Hypen, Ramodar, Tedolan, UNII:2M36281008, RAK-591

Etodolac (CAS 41340-25-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C17H21NO3 and a molecular weight of 287.353 g/mol. Key properties include a melting point of 145-1480C, a boiling point of 507.9±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 261.0±28.7 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 41340-25-4
Jingsj CID: J-32743-9
Molecular Formula: C₁₇H₂₁NO₃
Molecular Weight: 287.353 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	145-1480C
Boiling Point	507.9±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	261.0±28.7 °C
Exact Mass	287.152130
PSA	62.32000
LogP	3.59
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.597

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H319 — Causes serious eye irritation

Activity & Biological Data

Target	COX-2:41 nM (IC50, in CHO cells) COX-1:∼50000 nM (IC50, in CHO cells)
Additional Information	[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Ito S, Tajima K, Nogawa M et al. Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. J Pharmacol Exp Ther. 2012 Jul;342(1):53-60. [3]. Yanaoka K, Oka M, Yoshimura N et al. Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion. Int J Cancer. 2010 Mar 15;126(6):1467-73. [4]. Matsuyama M, Yoshimura R, Hase T et al. Administration of the selective cyclooxygenase (COX)-2 inhibitor etodolac prolongs cardiac allograft survival in a mouse model. Mol Med Report. 2010 Sep-Oct;3(5):771-4.

Target

COX-2:41 nM (IC50, in CHO cells) COX-1:∼50000 nM (IC50, in CHO cells)

Additional Information

[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Ito S, Tajima K, Nogawa M et al. Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. J Pharmacol Exp Ther. 2012 Jul;342(1):53-60. [3]. Yanaoka K, Oka M, Yoshimura N et al. Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion. Int J Cancer. 2010 Mar 15;126(6):1467-73. [4]. Matsuyama M, Yoshimura R, Hase T et al. Administration of the selective cyclooxygenase (COX)-2 inhibitor etodolac prolongs cardiac allograft survival in a mouse model. Mol Med Report. 2010 Sep-Oct;3(5):771-4.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Etodolac?

The CAS number of Etodolac is 41340-25-4.

What are the molecular formula and molecular weight of Etodolac?

Etodolac has molecular formula C17H21NO3 and molecular weight 287.353 g/mol.

Is Etodolac hazardous?

Etodolac has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Etodolac?

For Etodolac, Upstream Products: 7-Ethyltryptophol, Ethyl 3-oxovalerate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Etodolac (CAS 41340-25-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-32743-9 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.