Cimetidine hydrochloride

Also known as: Cimetidine HCl, Cimetidin-HCl, Cimetidine Hydrochloride (200 mg), Cimetidine Hydrochloride USP24, Cimetidinhydrochlorid, Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-, monohydrochloride, MFCD01724314, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine monohydrochloride, cimetex, 3-cyano-2-methyl-1-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine hydrochloride, SKF-92334

Cimetidine hydrochloride (CAS 70059-30-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C10H17ClN6S and a molecular weight of 288.8 g/mol. Key properties include a boiling point of 488ºC at 760 mmHg and a flash point of 248.9ºC. It is listed by 1 supplier, from 10,000.00 to 10,000.00 CNY per 0.2g. Record last updated Aug 21, 2026.

CAS No.: 70059-30-2
Jingsj CID: J-978868-6
Molecular Formula: C₁₀H₁₇ClN₆S
Molecular Weight: 288.8 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Supplier	Purity / Pack	Base Price	Unit Price	Origin
Maikuo Made to Order	99% 0.2g	¥2,000.00	$1,496.44 /gBest ¥10,000.00/g CNY	CN China MOQ 0.2g	View Product

Physicochemical Properties

Boiling Point	488ºC at 760 mmHg
Flash Point	248.9ºC
Exact Mass	288.09200
PSA	114.19000
LogP	2.18118
SMILES	CC1=C(N=CN1)CSCCNC(=NC)NC#N.Cl
InChIKey	QJHCNBWLPSXHBL-UHFFFAOYSA-N
InChI	1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H

Activity & Biological Data

Target	H2 Receptor:0.6 μM (Kd)
Additional Information	[1]. M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6802-7. [2]. Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70(2): p. 450-3. [3]. Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94(5): p. 585-92. [4]. Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54(1): p. 74-83. [5]. Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376. [6]. Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.

Target

H2 Receptor:0.6 μM (Kd)

Additional Information

[1]. M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6802-7. [2]. Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70(2): p. 450-3. [3]. Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94(5): p. 585-92. [4]. Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54(1): p. 74-83. [5]. Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376. [6]. Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.

Customs & Trade Information

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Cimetidine hydrochloride?

The CAS number of Cimetidine hydrochloride is 70059-30-2.

What are the molecular formula and molecular weight of Cimetidine hydrochloride?

Cimetidine hydrochloride has molecular formula C10H17ClN6S and molecular weight 288.8 g/mol.

Which suppliers offer Cimetidine hydrochloride?

1 supplier(s) listed; reference unit price ¥10000.00–10000.00 /g.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cimetidine hydrochloride (CAS 70059-30-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-978868-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.