Adefovir

Also known as: PMEA, GS-0393, ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid, 9-(2-Phosphonylmethoxyethyl)adenine, 9-[2-(Phosphonomethoxy)ethyl]adenine, P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid

Adefovir (CAS 106941-25-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C8H12N5O4P and a molecular weight of 273.186 g/mol. Key properties include a melting point of >260°C, a boiling point of 632.5±65.0 °C at 760 mmHg, a density of 1.9±0.1 g/cm3 and a flash point of 336.3±34.3 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 106941-25-7
Jingsj CID: J-32735-5
Molecular Formula: C₈H₁₂N₅O₄P
Molecular Weight: 273.186 g/mol
Category: Organic Compounds
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	>260°C
Boiling Point	632.5±65.0 °C at 760 mmHg
Density	1.9±0.1 g/cm3
Flash Point	336.3±34.3 °C
Exact Mass	273.062683
PSA	146.19000
LogP	-2.06
Vapor Pressure	0.0±2.0 mmHg at 25°C
Refractive Index	1.769
Storage Conditions	-20°C Freezer

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	HBV[1][2][3]; DNA polymerase[1][2]
Additional Information	[1]. X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327. [2]. Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16. [3]. Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.

Target

HBV[1][2][3]; DNA polymerase[1][2]

Additional Information

[1]. X.-X.Zhou, et al. 7.11 - Deoxyribonucleic Acid Viruses: Antivirals for Herpesviruses and Hepatitis B Virus. Comprehensive Medicinal Chemistry II. Volume 7, 2007, Pages 295-327. [2]. Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16. [3]. Leah A.Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Adefovir?

The CAS number of Adefovir is 106941-25-7.

What are the molecular formula and molecular weight of Adefovir?

Adefovir has molecular formula C8H12N5O4P and molecular weight 273.186 g/mol.

Is Adefovir hazardous?

Adefovir has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Adefovir?

For Adefovir, Upstream Products: Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate, 2-(6-aminopurin-9-yl)ethanol, Diethyl (tosyloxy)methylphosphonate; Downstream Products: Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate, Adefovir dipivoxil.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "Adefovir (CAS 106941-25-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-32735-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.