Adefovir dipivoxil

Also known as: 9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine, Bis(pivaloyloxymethyl)-9-[2-(phosphonomethoxy)ethyl]adenine, Bis POM PMEA, Hepsera, Preveon, MFCD00869897

Adefovir dipivoxil (CAS 142340-99-6) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C20H32N5O8P and a molecular weight of 501.470 g/mol. Key properties include a melting point of 98-102ºC, a boiling point of 641.0±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 341.5±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H312 — Harmful in contact with skin and H332 — Harmful if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 142340-99-6
Jingsj CID: J-1975726-7
Molecular Formula: C₂₀H₃₂N₅O₈P
Molecular Weight: 501.470 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	98-102ºC
Boiling Point	641.0±65.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	341.5±34.3 °C
Exact Mass	501.198853
PSA	176.79000
LogP	2.45
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.569
Storage Conditions	−20°C

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H332 — Harmful if inhaled

Activity & Biological Data

Additional Information	[1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16. [2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73. [3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38. [4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.

Additional Information

[1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16. [2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73. [3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38. [4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700.

Frequently Asked Questions

What is the CAS number of Adefovir dipivoxil?

The CAS number of Adefovir dipivoxil is 142340-99-6.

What are the molecular formula and molecular weight of Adefovir dipivoxil?

Adefovir dipivoxil has molecular formula C20H32N5O8P and molecular weight 501.470 g/mol.

Is Adefovir dipivoxil hazardous?

Adefovir dipivoxil has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H312 — Harmful in contact with skin; H332 — Harmful if inhaled.

What are the upstream and downstream products of Adefovir dipivoxil?

For Adefovir dipivoxil, Upstream Products: Chloromethyl pivalate, Adefovir, Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Adefovir dipivoxil (CAS 142340-99-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975726-7 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.