Estradiol

Also known as: 17β-Estradiol, β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Estradiol-17β, Oestradiol, Dihydrofolliculin, 17β-Oestradiol

Estradiol (CAS 50-28-2) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C18H24O2 and a molecular weight of 272.382 g/mol. Key properties include a melting point of 173ºC, a boiling point of 445.9±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 209.6±23.3 °C. It is classified under GHS with signal word Danger and hazard statements H351 — Suspected of causing cancer and H362. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 50-28-2
Jingsj CID: J-31545-8
Molecular Formula: C₁₈H₂₄O₂
Molecular Weight: 272.382 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	173ºC
Boiling Point	445.9±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	209.6±23.3 °C
Exact Mass	272.177643
PSA	40.46000
LogP	4.13
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.599

GHS Safety & Compliance

Health HazardSignal word: Danger

H351 — Suspected of causing cancer
H362

Activity & Biological Data

Target	Human Endogenous Metabolite
Additional Information	[1]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [3]. Girasole G, et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest. 1992 Mar;89(3):883-91. [4]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [5]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

Target

Human Endogenous Metabolite

Additional Information

[1]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [2]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [3]. Girasole G, et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest. 1992 Mar;89(3):883-91. [4]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [5]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

Frequently Asked Questions

What is the CAS number of Estradiol?

The CAS number of Estradiol is 50-28-2.

What are the molecular formula and molecular weight of Estradiol?

Estradiol has molecular formula C18H24O2 and molecular weight 272.382 g/mol.

Is Estradiol hazardous?

Estradiol has GHS signal word Danger and hazard statements H351 — Suspected of causing cancer; H362.

What are the upstream and downstream products of Estradiol?

For Estradiol, Upstream Products: Estrone, Boldenone, Estrone acetate; Downstream Products: 4-Hydroxyestradiol, 2-Hydroxyestradiol, Estriol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Estradiol (CAS 50-28-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-31545-8 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.