(-)-Epicatechin

Also known as: Epicatechin, L-Epicatechin, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol, (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol, (-)-cis-3,3',4',5,7-Pentahydroxyflavane, EC, MFCD00075648

(-)-Epicatechin (CAS 490-46-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H14O6 and a molecular weight of 290.268 g/mol. Key properties include a melting point of 240 °C (dec.)(lit.), a boiling point of 630.4±55.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 335.0±31.5 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 490-46-0
Jingsj CID: J-29845-3
Molecular Formula: C₁₅H₁₄O₆
Molecular Weight: 290.268 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	240 °C (dec.)(lit.)
Boiling Point	630.4±55.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	335.0±31.5 °C
Exact Mass	290.079041
PSA	110.38000
LogP	0.49
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.742

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	COX-1:3.2 μM (IC50)
Additional Information	[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. [3]. Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31.

Target

COX-1:3.2 μM (IC50)

Additional Information

[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. [3]. Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31.

Frequently Asked Questions

What is the CAS number of (-)-Epicatechin?

The CAS number of (-)-Epicatechin is 490-46-0.

What are the molecular formula and molecular weight of (-)-Epicatechin?

(-)-Epicatechin has molecular formula C15H14O6 and molecular weight 290.268 g/mol.

Is (-)-Epicatechin hazardous?

(-)-Epicatechin has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of (-)-Epicatechin?

For (-)-Epicatechin, Upstream Products: Procyanidin B4, (-)-Epigallocatechin gallate, (+)-Catechin; Downstream Products: 1,1-diphenyl-2-picrylhydrazine, 3-(3-Hydroxyphenyl)propionic acid, S-Adenosyl-L-homocysteine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(-)-Epicatechin (CAS 490-46-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-29845-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.