2,3-bis(4-hydroxyphenyl)propionitrile

Also known as: 2,3-bis(4-hydroxyphenyl)propanenitrile, 2,3-bis(p-hydroxyphenyl)propionitrile, 4-hydroxy-α-(4-hydroxyphenyl)benzenepropanenitrile, Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-, Diarylpropionitrile, SC-4473

2,3-bis(4-hydroxyphenyl)propionitrile (CAS 1428-67-7) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C15H13NO2 and a molecular weight of 239.269 g/mol. Key properties include a melting point of 203°C, a boiling point of 449.4±35.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 225.6±25.9 °C. It is classified under GHS with signal word Warning and hazard statements H319 — Causes serious eye irritation and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1428-67-7
Jingsj CID: J-24966-7
Molecular Formula: C₁₅H₁₃NO₂
Molecular Weight: 239.269 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	203°C
Boiling Point	449.4±35.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	225.6±25.9 °C
Exact Mass	239.094635
PSA	64.25000
LogP	2.06
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.640
Storage Conditions	-20°C

GHS Safety & Compliance

Irritant / Environmental HazardSignal word: Warning

H319 — Causes serious eye irritation
H400 — Very toxic to aquatic life

Activity & Biological Data

Additional Information	[1]. Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9. [2]. Khalaj AJ, et al. Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30. [3]. Huang SY, et al. Estrogen receptor β agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor κB activation. Fertil Steril.

Additional Information

[1]. Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9. [2]. Khalaj AJ, et al. Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30. [3]. Huang SY, et al. Estrogen receptor β agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor κB activation. Fertil Steril.

Frequently Asked Questions

What is the CAS number of 2,3-bis(4-hydroxyphenyl)propionitrile?

The CAS number of 2,3-bis(4-hydroxyphenyl)propionitrile is 1428-67-7.

What are the molecular formula and molecular weight of 2,3-bis(4-hydroxyphenyl)propionitrile?

2,3-bis(4-hydroxyphenyl)propionitrile has molecular formula C15H13NO2 and molecular weight 239.269 g/mol.

Is 2,3-bis(4-hydroxyphenyl)propionitrile hazardous?

2,3-bis(4-hydroxyphenyl)propionitrile has GHS signal word Warning and hazard statements H319 — Causes serious eye irritation; H400 — Very toxic to aquatic life.

What are the upstream and downstream products of 2,3-bis(4-hydroxyphenyl)propionitrile?

For 2,3-bis(4-hydroxyphenyl)propionitrile, Upstream Products: 4-Methoxybenzyl bromide, (4-Methoxyphenyl)acetonitrile.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2,3-bis(4-hydroxyphenyl)propionitrile (CAS 1428-67-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-24966-7 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.