Trimethylsilyl trifluoroacetate
Also known as: Trifluoroacetic acid trimethylsilyl ester, Acetic acid, 2,2,2-trifluoro-, trimethylsilyl ester, Acetic acid, trifluoro-, trimethylsilyl ester, Trimethylsilyltrifluoroacetate, EINECS 206-923-7, MFCD00000413
Trimethylsilyl trifluoroacetate (CAS 400-53-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C5H9F3O2Si and a molecular weight of 186.204 g/mol. Key properties include a boiling point of 89.0±0.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of -0.6±0.0 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour and H314 — Causes severe skin burns and eye damage. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 400-53-3
- Jingsj CID
- J-22386-9
- Molecular Formula
- C5H9F3O2Si
- Molecular Weight
- 186.204 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 89.0±0.0 °C at 760 mmHg |
|---|---|
| Density | 1.1±0.1 g/cm3 |
| Flash Point | -0.6±0.0 °C |
| Exact Mass | 186.032394 |
| PSA | 26.30000 |
| LogP | 2.76 |
| Additional Property | >1 (vs air) |
| Vapor Pressure | 59.7±0.1 mmHg at 25°C |
| Refractive Index | 1.353 |
GHS Safety & Compliance
- H225 — Highly flammable liquid and vapour
- H314 — Causes severe skin burns and eye damage
Frequently Asked Questions
What is the CAS number of Trimethylsilyl trifluoroacetate?
The CAS number of Trimethylsilyl trifluoroacetate is 400-53-3.
What are the molecular formula and molecular weight of Trimethylsilyl trifluoroacetate?
Trimethylsilyl trifluoroacetate has molecular formula C5H9F3O2Si and molecular weight 186.204 g/mol.
Is Trimethylsilyl trifluoroacetate hazardous?
Trimethylsilyl trifluoroacetate has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H314 — Causes severe skin burns and eye damage.
What are the upstream and downstream products of Trimethylsilyl trifluoroacetate?
For Trimethylsilyl trifluoroacetate, Upstream Products: Bis(trimethylsilyl) sulfate, Sodium trifluoroacetate, Trifluoroacetyl chloride; Downstream Products: Hexamethyldisiloxane, n-Butyl trifluoroacetate, Ethyl 4,4,4-trifluoroacetoacetate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Trimethylsilyl trifluoroacetate (CAS 400-53-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-22386-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.