Fasudil
Also known as: Fasudilum, HA-1077, AT877, 1-(5-Isoquinolinylsulfonyl)homopiperazine, 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline, (5-Isoquinolinesulfonyl)homopiperazine, 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline, 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine
Fasudil (CAS 103745-39-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H17N3O2S and a molecular weight of 291.37 g/mol. Key properties include a boiling point of 506.2±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 259.9±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 103745-39-7
- Jingsj CID
- J-1993862-6
- Molecular Formula
- C14H17N3O2S
- Molecular Weight
- 291.37 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 506.2±60.0 °C at 760 mmHg |
|---|---|
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 259.9±32.9 °C |
| PSA | 70.68000 |
| LogP | 1.19 |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
| Refractive Index | 1.622 |
| Storage Conditions | Store at RT |
| Additional Property | H2O: >200 mg/mL |
Activity & Biological Data
| Target | p160ROCK:0.33 μM (Ki) PKA:1 μM (Ki) PKC:9.3 μM (Ki) MLCK:55 μM (Ki) |
|---|---|
| Additional Information | [1]. Ono-Saito N, et al. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther. 1999 May-Jun;82(2-3):123-31. [2]. Asano T, et al. Mechanism of action of a novel antivasospasm drug, HA1077. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40. [3]. Asano T, et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 1989 Dec;98(4):1091-100. [4]. Negoro N, et al. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):211-5. [5]. Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. [6]. Zhang J, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80. [7]. Sun X, et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34. [8]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Fasudil?
The CAS number of Fasudil is 103745-39-7.
What are the molecular formula and molecular weight of Fasudil?
Fasudil has molecular formula C14H17N3O2S and molecular weight 291.37 g/mol.
What are the upstream and downstream products of Fasudil?
For Fasudil, Upstream Products: Homopiperazine, isoquinoline-5-sulfonyl chloride, Isoquinoline-5-sulfonyl chloride hydrochloride; Downstream Products: Fasudil hydrochloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Fasudil (CAS 103745-39-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1993862-6 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.