Tenofovir Disoproxil Fumarate

Also known as: Tenofovir DF, TDF, Viread, Tenofovir dipivoxil fumarate, Tenofovir diisoproxil fumarate, 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate, Bis{[(isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate (1:1), GS-4331-05, AIDS031697

Tenofovir Disoproxil Fumarate (CAS 202138-50-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C23H34N5O14P and a molecular weight of 635.515 g/mol. Key properties include a melting point of 219ºC, a boiling point of 642.7ºC at 760 mmHg, a density of 1.45 g/cm3 and a flash point of 342.5ºC. It is classified under GHS with signal word Danger and hazard statements H318 — Causes serious eye damage. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 202138-50-9
Jingsj CID: J-1986851-0
Molecular Formula: C₂₃H₃₄N₅O₁₄P
Molecular Weight: 635.515 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	219ºC
Boiling Point	642.7ºC at 760 mmHg
Density	1.45 g/cm3
Flash Point	342.5ºC
Exact Mass	635.183960
PSA	269.85000
LogP	3.32860
Vapor Pressure	2.06E-16mmHg at 25°C
Storage Conditions	Refrigerator

GHS Safety & Compliance

CorrosionSignal word: Danger

H318 — Causes serious eye damage

Activity & Biological Data

Additional Information	[1]. Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3) [2]. Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018 [3]. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098 [4]. Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8. [5]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.

Additional Information

[1]. Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3) [2]. Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018 [3]. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098 [4]. Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8. [5]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Tenofovir Disoproxil Fumarate?

The CAS number of Tenofovir Disoproxil Fumarate is 202138-50-9.

What are the molecular formula and molecular weight of Tenofovir Disoproxil Fumarate?

Tenofovir Disoproxil Fumarate has molecular formula C23H34N5O14P and molecular weight 635.515 g/mol.

Is Tenofovir Disoproxil Fumarate hazardous?

Tenofovir Disoproxil Fumarate has GHS signal word Danger and hazard statements H318 — Causes serious eye damage.

What are the upstream and downstream products of Tenofovir Disoproxil Fumarate?

For Tenofovir Disoproxil Fumarate, Upstream Products: Chloromethyl isopropyl carbonate, Fumaric acid, Tenofovir.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tenofovir Disoproxil Fumarate (CAS 202138-50-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986851-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.